korrents

dementia

Alzheimer's, Parkinson's and cognitive decline: what raises the risk, what is preventable, and what ageing well protects.

FilterEveryone, all time20 from 8 people
Group All Scientists 1Founders & executives 1
Who Everyone TWTommy Wood 6 MHMasud Husain 4 ACAlan Castel 3 MHMax Hodak 2 RBRoy Baumeister 2 DSDerek Sivers 1 ETEric Topol 1 JTJacob Trefethen 1
When All time Past 1 yearPast 3 yearsPast 5 years
  1. MH

    Masud Husain quoted

    Professor of Neurology at the University of Oxford

    Our readingThe slowness of Parkinson's disease may be a failure of motivation to act rather than of motor control, which is why a patient can still run from a burning house.

    motivation

    Their wordsSo it's a different way of framing why is there a reduction of action? Why is there bradicynesia, a slowing of movement in people with Parkinson's disease? That's really interesting. It doesn't just have to be about motor control. It could be the motivation to act just as we said with David, right?

    ↗How to Improve Motivation & Overcome Procrastination | Dr. Masud Husainyoutube.com 17th of 24 in this recording

  3. MH

    Masud Husain quoted

    Our readingAlzheimer's disease and dementia are not the same thing: a fifth to a third of people whose brains carry the pathology never became demented.

    Their wordsAlzheimer's disease does not necessarily equal dementia. people can have Alzheimer's disease and not get dementia. So, we found this out from post-mortem studies. People have been followed as they age. Uh they've donated their brains and it turns out that perhaps 20 to 30% of these individuals who never had dementia have Alzheimer pathology.

    ↗How to Improve Motivation & Overcome Procrastination | Dr. Masud Husainyoutube.com 21st of 24 in this recording

  5. MH

    Masud Husain quoted

    Our readingKeeping a social network, staying curious and having a sense of purpose protect against dementia about as much as blood pressure and exercise do.

    Their wordsThose include that having that sense of purpose, making sure that you have a network of people, that you're socially connected as your age, and also remaining curious, open to new ideas. Those factors turn out to be almost as important as some of the physical things we do.

    ↗How to Improve Motivation & Overcome Procrastination | Dr. Masud Husainyoutube.com 22nd of 24 in this recording

  7. MH

    Masud Husain quoted

    Our readingApathy in an otherwise healthy older person doubles their risk of Alzheimer's, which means the disease changes behaviour long before it touches cognition.

    motivation

    Their wordsWhat we find is that those individuals who score highly on just self-reported questionnaires for motivation, if they score highly for apathy, they have twice the risk of developing Alzheimer's disease than people who don't.

    ↗How to Improve Motivation & Overcome Procrastination | Dr. Masud Husainyoutube.com 23rd of 24 in this recording

  8. 4 days earlier
  9. MH

    Max Hodak quoted

    Co-founder and chief executive of Science

    Our readingHumanity is not good enough at molecular biology to make drugs that restore vision or hearing or stop Parkinson's.

    Their wordsPeople have spent huge amounts of time and money looking for drugs to restore vision or to restore hearing or to stop Parkinson's or to to help paralyzed people move again. Understanding the like the biology and the molecular detail required to make a drug has been very difficult. Humanity just isn't that good at that, to be totally honest.

    ↗From Restoring Sight to Reimagining the Brain, with Max Hodakyoutube.com 2nd of 18 in this recording

  10. 8 days earlier
  11. ET

    Eric Topol quoted

    Cardiologist, founder and director of the Scripps Research…

    Our readingBrain ageing is not gradual wear: around midlife the brain's original immune cells are replaced by inflammatory cells that came from the blood.

    Their wordsThe original brain microglia (Micro1) are replaced by transformed monocytes (Micro 2) that are highly inflammatory.

    ↗Why Our Memory Slips After Age 50erictopol.substack.com

  12. 5 days earlier
  13. MH

    Max Hodak quoted

    Our readingTreating the brain directly as a computer produces effect sizes medicine does not otherwise see — a deep brain stimulator takes a patient from unable to hold a cup of water to writing cursive in ten seconds.

    Their wordsIt gives you these effect sizes that you just don't really see in medicine. Like if you have a patient on on a dopamineergic drug for Parkinson's that works for some period of time, but it's a it's a relatively small effect after a little while. You turn on a deep brain stimulator and a patient goes from not being able to hold a cup of water to being able to write cursive in like 10 seconds.

    ↗Max Hodak: Average Is Not Good Enoughyoutube.com 18th of 22 in this recording

  14. 3 weeks earlier
  15. TW

    Tommy Wood quoted

    Associate professor at the University of Washington

    Our readingTraining visual processing speed in later life lowers dementia risk two decades later, which continuing to do what you are already good at does not.

    Their wordsThey just published a secondary analysis of the active trial that showed that um those who did processing speed training with uh booster sessions at one and three years had a significantly decreased risk of dementia 20 years later.

    ↗Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Woodyoutube.com 4th of 26 in this recording

  17. TW

    Tommy Wood quoted

    Our readingPartner dancing, not puzzles, has the best evidence of any activity for improving cognitive function in older adults.

    Their wordsthere are meta analyses of these interventions in older adults showing that ballroom and line dancing have the greatest effect on cognitive function. And so both of those require other people as well as learning you know various sets of of movements.

    ↗Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Woodyoutube.com 7th of 26 in this recording

  19. TW

    Tommy Wood quoted

    Our readingNo single food explains the link between a Mediterranean diet and lower dementia risk, so what matters is overall diet quality rather than olive oil or avoiding meat.

    Their wordsAnd there was no food or you know olive oil or food group or you eating more or less meat that changed the relationship between the Mediterranean diet and dementia risk. So what that tells me is it's much more about whole foods.

    ↗Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Woodyoutube.com 14th of 26 in this recording

  21. TW

    Tommy Wood quoted

    Our readingAbout half of all dementia is preventable, and most of that preventable half is Alzheimer's disease and vascular dementia.

    Their wordswe've gotten to a point now where it's generally accepted that potentially half of cases of dementia are preventable and I think the majority of that falls into those first two buckets Alzheimer's and vascular dementia

    ↗Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Woodyoutube.com 23rd of 26 in this recording

  23. TW

    Tommy Wood quoted

    Our readingThe dementia risk from short sleep starts below six hours a night, not below eight.

    Their wordsbut I mean in reality when you look at the data on sleep loss and dementia risk The cut off is really around 6 hours. So if you're consistently sleeping fewer than 6 hours, that's where risk starts to increase.

    ↗Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Woodyoutube.com 24th of 26 in this recording

  25. TW

    Tommy Wood quoted

    Our readingCognitive decline is a staircase rather than a slope: the big drops happen after episodes of serious illness.

    Their wordscognitive function doesn't just decline sort of linearly or steadily with age. It goes down, you know, a little bit on average, but the biggest decreases sort of happen stepwise after periods of significant illness.

    ↗Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Woodyoutube.com 25th of 26 in this recording

  26. 7 days earlier
  27. AC

    Alan Castel quoted

    Professor of psychology at UCLA

    Our readingAlzheimer's pathology in the brain does not settle whether a person has dementia: the nuns' brains were full of plaques and tangles while they went on functioning normally.

    Their wordsand you found that these nuns, how they aged, some of them certainly when they passed away, their brains had these kind of hallmark signs of dementia, plaques and tangles, but behaviorally they were still high functioning. So, it's really interesting that the hardware shows what we see as dementia and specifically Alzheimer's disease, but their behavior uh was that of a fairly healthy cognitive person.

    ↗How to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castelyoutube.com 11th of 24 in this recording

  29. AC

    Alan Castel quoted

    Our readingBalance, not memory, is what middle-aged and older people should be worrying about, and almost nobody knows what state theirs is in.

    Their wordsAnd I think, you know, most people when they talk about aging, they're so worried about dementia and, you know, Alzheimer's disease as a specific form, but balance is even more important, I think. And most people aren't even aware of their balance.

    ↗How to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castelyoutube.com 13th of 24 in this recording

  31. AC

    Alan Castel quoted

    Our readingBelieving that ageing goes well is itself protective: people with a positive attitude to ageing live longer and are less likely to develop dementia.

    Their wordsAnd actually, more recent research shows that those who have a positive attitude live longer, they're less likely to develop dementia.

    ↗How to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castelyoutube.com 20th of 24 in this recording

  32. 11 months earlier
  33. JT

    Jacob Trefethen quoted

    Head of global health R&D at Open Philanthropy

    Our readingRapid AI progress does not automatically produce rapid medical progress; without complementary investment, people still get cancer and Alzheimer's.

    Their wordsRapid AI progress does not automatically mean rapid medical progress. If the point of AI progress is human flourishing, we must make other complementary investments too.

    ↗What does AI progress mean for medical progress?blog.jacobtrefethen.com 1st of 2 in this piece

  34. 3 months earlier
  35. DS

    Derek Sivers quoted

    Founded CD Baby in 1998 and sold it in 2008

    Our readingBiological age is moot; people from about 17 with an adult mind until senility or dementia are all pretty much equal.

    Their wordsYour actual biological age is really moot. Anybody over the age of, I don't know, 17 that has a pretty adult mind, all the way up until you're senile and getting Alzheimer's or dementia, anything between there, we're all pretty much equal.

    ↗sive.rs

  36. 24 months earlier
  37. RB

    Roy Baumeister quoted

    American social psychologist, born 16 May 1953

    Our readingAging has two new dangers that emerged from changes in society: outliving your money and outliving your brain

    Their wordsBut just in the past couple decades, aging has developed two new dangers. Both have only emerged as a result of fundamental changes in society. In a nutshell, the two new threats are outliving your money, and outliving your brain.

    ↗Modern Aging Has Two Very New Dangers (Psychology Today, Cultural Animal)psychologytoday.com 1st of 2 in this piece

  39. RB

    Roy Baumeister quoted

    Our readingAs people live longer by caring for their bodies, dementia will claim larger and larger numbers

    Their wordsWhen most people died before 70, only a small and unfortunate minority got dementia. But now that people take better care of their bodies, such that increasing numbers manage to live until 90 or 100, dementia will claim larger and larger numbers.

    ↗Modern Aging Has Two Very New Dangers (Psychology Today, Cultural Animal)psychologytoday.com 2nd of 2 in this piece