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Their wordsEpigenetic clocks are remarkably informative across 348 mammalian species, including humans, for predicting maximal lifespan and life history, but we didn't know what they are actually measuring. It turns out it's PRC2, the pace of slow layer erosion!
Their wordsIt follows that lifestyle factors, like a pro-inflammatory diet, lack of exercise, or poor sleep quality, can be viewed as chronic stressors that could promote the slow layer erosion and accelerate the loss of cell identity.
Their wordsUndoubtedly, loss of cell identity is a major underpinning of age-related diseases.
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