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Eric Topol

@eric-topol · 9 positions · 0 changes of mind

Cardiologist, founder and director of the Scripps Research Translational Institute, and author of Super Agers. Writes Ground Truths, a free newsletter reviewing new medical research.

Eric Topol did not write this page.

We collected these quotes from things they published elsewhere, and every quote links to where it was said. They have no account here and have not endorsed this site. Quotes are word for word; the short line under each one is our own restatement, not their wording. Their own site. Is this you? Claim it or ask us to remove it. Or tell us what is wrong here.

  1. Our reading

    A drug that moves a surrogate blood marker in the right direction cannot be assumed to prevent heart attacks and strokes.

    Their wordsWe can’t count on surrogate blood markers to guide the results of cardiovascular clinical outcome trials.

    ↗The Coronary Artery Inflammation Controversyerictopol.substack.com 1st of 3 in this piece

    Interesting

  3. Our reading

    Inflammation's role in coronary artery disease is proven, not hypothetical; what is missing is a safe and potent way to reduce it.

    Their wordsThe “inflammation hypothesis” is not a hypothesis.

    ↗The Coronary Artery Inflammation Controversyerictopol.substack.com 2nd of 3 in this piece

    Interesting

  5. Our reading

    A coronary calcium score of zero does not mean the arteries are free of disease, and in a younger adult it is far weaker reassurance than it looks.

    Their wordsWe know that arteries with a calcium (CAC) score of zero can be highly inflamed, and that high CAC scores are not necessarily high-risk for cardiovascular events.

    ↗The Coronary Artery Inflammation Controversyerictopol.substack.com 3rd of 3 in this piece

    Interesting
  6. 3 weeks earlier

  7. Our reading

    Brain ageing is not gradual wear: around midlife the brain's original immune cells are replaced by inflammatory cells that came from the blood.

    Their wordsThe original brain microglia (Micro1) are replaced by transformed monocytes (Micro 2) that are highly inflammatory.

    ↗Why Our Memory Slips After Age 50erictopol.substack.com

    Interesting
  8. 4 weeks earlier

  9. Our reading

    Our organs and cell types age at different rates, so a single chronological age is an illusion.

    Their wordsIt also turns out our organs age at a different pace.

    ↗Medicine is Moving From Calendars to Clockserictopol.substack.com 1st of 4 in this piece

    Interesting

  11. Our reading

    The brain and the immune system act as the master regulators of ageing: when they age at a normal pace, survival over the following 15 years is near total.

    Their wordsAccordingly, the brain and immune system have the appearance of master regulators of the aging process.

    ↗Medicine is Moving From Calendars to Clockserictopol.substack.com 2nd of 4 in this piece

    Interesting

  13. Our reading

    Nobody should buy a direct-to-consumer biological age test today: they are sold expensively without standardisation or demonstrated reliability.

    Their wordsI would suggest not buying any of these tests.

    ↗Medicine is Moving From Calendars to Clockserictopol.substack.com 3rd of 4 in this piece

    Interesting

  15. Our reading

    Measurable, modifiable biological age at the organ and cell level is the most important advance yet in the science of human ageing.

    Their wordsI believe this represents the most important advance we have yet seen in the science of human aging.

    ↗Medicine is Moving From Calendars to Clockserictopol.substack.com 4th of 4 in this piece

    Interesting
  16. 4 weeks earlier

  17. Our reading

    Cancer can be predicted from blood proteins years before diagnosis, and that is what will finally make primary prevention of cancer possible.

    Their wordsOnce we can accurately predict cancer 5+ years ahead, the era of primary prevention will go into high gear.

    ↗A New Path to Preventing Cancererictopol.substack.com

    Interesting