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← Pharmaceutical R&D productivity has fallen for decades: far more money…
17 connected korrents · 13 moments on record from 8 Mar 2012 to 21 Jul 2026.
Everything filed under Psychotherapy
Psychotherapy
Everything filed under design
design
Everything filed under CBT
CBT
Everything filed under EMDR
EMDR Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once. — tap to centre the map on it The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and… Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. — tap to centre the map on it Every new drug has to beat the cheap generics that came before it, and that competition with our own back… Last stated 14 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. — tap to centre the map on it Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while… Last stated 14 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the… Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. — tap to centre the map on it How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose… Last stated 6 months ago
28 Feb 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and… Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: A drug discovery scientist starting today will probably retire without ever having worked on a drug that reached the market. — tap to centre the map on it A drug discovery scientist starting today will probably retire without ever having worked on a drug that reached… Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: R&D spending varies more than tenfold across diseases for no good reason, which is where the best opportunities in science funding are. — tap to centre the map on it R&D spending varies more than tenfold across diseases for no good reason, which is where the best opportunities in… Last stated a year ago
29 May 2025
JT
Jacob Trefethen — holds since 2025-05-29 — tap for who they are
Same subject: "Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic". — tap to centre the map on it "Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for… Last stated 13 years ago
2 Oct 2013
JS
Jonathan Shedler — holds since 2013-10-02 — tap for who they are
Same subject: A prescriber cannot outsource containment to the therapy hour: the emotional and relational dynamics are part of prescribing, not an intrusion on it. — tap to centre the map on it A prescriber cannot outsource containment to the therapy hour: the emotional and relational dynamics are part… Last stated 2 months ago
5 Jul 2026
AA
Awais Aftab — holds since 2026-07-05 — tap for who they are
Same subject: Character is not fixed: therapy works because habitual neural pathways can re-form, sometimes within minutes. — tap to centre the map on it Character is not fixed: therapy works because habitual neural pathways can re-form, sometimes within minutes. Last stated 3 years ago
11 Aug 2023
TR
Terry Real — holds since 2023-08-11 — tap for who they are
Same subject: Action comes before motivation: you do first and feel afterwards, not the other way round. — tap to centre the map on it Action comes before motivation: you do first and feel afterwards, not the other way round. Last stated 11 months ago
30 Sept 2025
LF
Lex Fridman — holds since 2025-09-30 — tap for who they are
Same subject: No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often. — tap to centre the map on it No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied… Last stated 13 years ago
2 Oct 2013
JS
Jonathan Shedler — holds since 2013-10-02 — tap for who they are
Same subject: A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work. — tap to centre the map on it A therapy is only shown to be more effective if it is compared against another treatment intended to help… Last stated 2 years ago
11 Sept 2024
SM
Scott D. Miller — holds since 2024-09-11 — tap for who they are
Same subject: Eye movement reprocessing went from alternative to establishment, and moving your eyes while talking about a trauma does seem to help you process it. — tap to centre the map on it Eye movement reprocessing went from alternative to establishment, and moving your eyes while talking about a… Last stated 7 years ago
12 Nov 2019
SA
Scott Alexander — holds since 2019-11-12 — tap for who they are
Same subject: If negative emotion comes from underweighting sensory evidence, that explains EMDR: it forces high-precision attention onto something the mind usually represses. — tap to centre the map on it If negative emotion comes from underweighting sensory evidence, that explains EMDR: it forces high-precision… Last stated 6 years ago
13 Feb 2021
SA
Scott Alexander — holds since 2021-02-13 — tap for who they are
Same subject: Somebody with trauma should try a trauma-focused therapy such as EMDR before treating their nightmares directly. — tap to centre the map on it Somebody with trauma should try a trauma-focused therapy such as EMDR before treating their nightmares directly. Last stated 4 years ago
16 Jun 2022
SA
Scott Alexander — holds since 2022-06-16 — tap for who they are
At the centre
Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.
Holds AT Alex TelfordRT Ruxandra TesloRead this korrent →
The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once.
Holds AT Alex Telford
Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time.
Holds DL Derek Lowe
Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them.
Holds DL Derek Lowe
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds AT Alex TelfordRT Ruxandra Teslo
How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly.
Holds AT Alex TelfordRT Ruxandra Teslo
Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.
Holds RT Ruxandra Teslo
A drug discovery scientist starting today will probably retire without ever having worked on a drug that reached the market.
Holds AT Alex Telford
R&D spending varies more than tenfold across diseases for no good reason, which is where the best opportunities in science funding are.
Holds JT Jacob Trefethen
"Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic".
Holds JS Jonathan Shedler
A prescriber cannot outsource containment to the therapy hour: the emotional and relational dynamics are part of prescribing, not an intrusion on it.
Holds AA Awais Aftab
Character is not fixed: therapy works because habitual neural pathways can re-form, sometimes within minutes.
Holds TR Terry Real
Action comes before motivation: you do first and feel afterwards, not the other way round.
Holds LF Lex Fridman
No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often.
Holds JS Jonathan Shedler
A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work.
Holds SM Scott D. Miller
Eye movement reprocessing went from alternative to establishment, and moving your eyes while talking about a trauma does seem to help you process it.
Holds SA Scott Alexander
If negative emotion comes from underweighting sensory evidence, that explains EMDR: it forces high-precision attention onto something the mind usually represses.
Holds SA Scott Alexander
Somebody with trauma should try a trauma-focused therapy such as EMDR before treating their nightmares directly.
Holds SA Scott Alexander