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← Pharmaceutical R&D productivity has fallen for decades: far more money…
17 connected korrents · 14 moments from 8 Mar 2012 to 17 Sept 2026.
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Psychotherapy Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Last stated 3 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Drug discovery has become less efficient over time despite continued technological progress. — tap to centre the map on it Drug discovery has become less efficient over time despite continued technological progress. Last stated 9 months ago
18 Jan 2026
EH
Elliot Hershberg — holds since 2026-01-18 — tap for who they are
Same subject: The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once. — tap to centre the map on it The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. — tap to centre the map on it Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: New technologies can meaningfully improve R&D productivity in drug development. — tap to centre the map on it New technologies can meaningfully improve R&D productivity in drug development. Last stated 6 months ago
12 Apr 2026
EH
Elliot Hershberg — holds since 2026-04-12 — tap for who they are
Same subject: Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. — tap to centre the map on it Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 3 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. — tap to centre the map on it How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. Last stated 8 months ago
28 Feb 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. Last stated 8 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: A feeling of responsibility is probably the greatest inhibitor of creativity; great ideas came from people not paid to have them — tap to centre the map on it A feeling of responsibility is probably the greatest inhibitor of creativity; great ideas came from people not paid to have them
IA
Isaac Asimov — holds since c. 1959 — tap for who they are
Same subject: A free-wheeling, anarchic neural organization may be the secret of human creativity, at the price of susceptibility to mental illness — tap to centre the map on it A free-wheeling, anarchic neural organization may be the secret of human creativity, at the price of susceptibility to mental illness Last stated 14 years ago
8 Jan 2013
DD
Daniel Dennett — holds since 2013-01-08 — tap for who they are
Same subject: A thought experiment serves to encourage speculation and logical thinking and to change paradigms. — tap to centre the map on it A thought experiment serves to encourage speculation and logical thinking and to change paradigms. Last stated 5 years ago
1 Feb 2022
SP
Shane Parrish — holds since 2022-02-01 — tap for who they are
Same subject: A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI. — tap to centre the map on it A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI. Last stated 10 months ago
1 Jan 2026
JL
Jason Lemkin — holds since 2026-01-01 — tap for who they are
Same subject: A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to. — tap to centre the map on it A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to. Last stated 3 months ago
15 Jul 2026
DH
Dex Horthy — holds since 2026-07-15 — tap for who they are
Same subject: A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls. — tap to centre the map on it A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls. Last stated a month ago
17 Sept 2026
PC
Patrick Collison — holds since 2026-09-17 — tap for who they are
Same subject: "If you're not growing, you're dying" is truer of the person than of the company. — tap to centre the map on it "If you're not growing, you're dying" is truer of the person than of the company. Last stated 9 months ago
25 Jan 2026
JC
Jason Cohen — holds since 2026-01-25 — tap for who they are
Same subject: A common-sense utopia is much closer to the present day than it is to the best futures actually available to us. — tap to centre the map on it A common-sense utopia is much closer to the present day than it is to the best futures actually available to us. Last stated a year ago
3 Aug 2025
WM
William MacAskill — holds since 2025-08-03 — tap for who they are
Same subject: A company can run at a fast pace sustainably without constant overwork or undue stress — tap to centre the map on it A company can run at a fast pace sustainably without constant overwork or undue stress Last stated 4 years ago
4 Nov 2022
DH
David Heinemeier Hansson — holds since 2022-11-04 — tap for who they are
At the centre
Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.
Holds Read this korrent →
Drug discovery has become less efficient over time despite continued technological progress.
Holds
The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once.
Holds
Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time.
Holds
New technologies can meaningfully improve R&D productivity in drug development.
Holds
Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them.
Holds
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds
How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly.
Holds
Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.
Holds
A feeling of responsibility is probably the greatest inhibitor of creativity; great ideas came from people not paid to have them
Last stated c. 1959
Holds
A free-wheeling, anarchic neural organization may be the secret of human creativity, at the price of susceptibility to mental illness
Holds
A thought experiment serves to encourage speculation and logical thinking and to change paradigms.
Holds
A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI.
Holds
A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to.
Holds
A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls.
Holds
"If you're not growing, you're dying" is truer of the person than of the company.
Holds
A common-sense utopia is much closer to the present day than it is to the best futures actually available to us.
Holds
A company can run at a fast pace sustainably without constant overwork or undue stress
Holds