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← Drug research is heading, at speed, for a world in which fewer and…
17 connected korrents · 14 moments on record from 11 Jun 2006 to 26 Jul 2026.
Everything filed under Psychotherapy
Psychotherapy
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simplicity
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CBT Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. — tap to centre the map on it Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. — tap to centre the map on it Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. — tap to centre the map on it How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. Last stated 6 months ago
28 Feb 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. — tap to centre the map on it Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. Last stated 2 months ago
21 Jul 2026
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Because research is concentrated in rich countries, both what we know and what gets made are skewed away from the diseases of poor ones. — tap to centre the map on it Because research is concentrated in rich countries, both what we know and what gets made are skewed away from the diseases of poor ones. Last stated a year ago
2 Aug 2025
JT
Jacob Trefethen — holds since 2025-08-02 — tap for who they are
Same subject: A million copies of one researcher would hit diminishing returns quickly, because what research needs is people who think differently. — tap to centre the map on it A million copies of one researcher would hit diminishing returns quickly, because what research needs is people who think differently. Last stated 9 months ago
25 Nov 2025
IS
Ilya Sutskever — holds since 2025-11-25 — tap for who they are
Same subject: "Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic". — tap to centre the map on it "Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic". Last stated 13 years ago
2 Oct 2013
JS
Jonathan Shedler — holds since 2013-10-02 — tap for who they are
Same subject: A prescriber cannot outsource containment to the therapy hour: the emotional and relational dynamics are part of prescribing, not an intrusion on it. — tap to centre the map on it A prescriber cannot outsource containment to the therapy hour: the emotional and relational dynamics are part of prescribing, not an intrusion on it. Last stated 2 months ago
5 Jul 2026
AA
Awais Aftab — holds since 2026-07-05 — tap for who they are
Same subject: Character is not fixed: therapy works because habitual neural pathways can re-form, sometimes within minutes. — tap to centre the map on it Character is not fixed: therapy works because habitual neural pathways can re-form, sometimes within minutes. Last stated 3 years ago
11 Aug 2023
TR
Terry Real — holds since 2023-08-11 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Convergence and simplicity make for poor goals in technology; aim for clarity instead. — tap to centre the map on it Convergence and simplicity make for poor goals in technology; aim for clarity instead. Last stated 12 years ago
18 Feb 2015
FC
Frank Chimero — holds since 2015-02-18 — tap for who they are
Same subject: Savings in time feel like simplicity: when forced to wait, life seems unnecessarily complex. — tap to centre the map on it Savings in time feel like simplicity: when forced to wait, life seems unnecessarily complex. Last stated 20 years ago
11 Jun 2006
JM
John Maeda — holds since 2006-06-11 — tap for who they are
Same subject: Action comes before motivation: you do first and feel afterwards, not the other way round. — tap to centre the map on it Action comes before motivation: you do first and feel afterwards, not the other way round. Last stated 11 months ago
30 Sept 2025
LF
Lex Fridman — holds since 2025-09-30 — tap for who they are
Same subject: No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often. — tap to centre the map on it No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often. Last stated 13 years ago
2 Oct 2013
JS
Jonathan Shedler — holds since 2013-10-02 — tap for who they are
Same subject: A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work. — tap to centre the map on it A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work. Last stated 2 years ago
11 Sept 2024
SM
Scott D. Miller — holds since 2024-09-11 — tap for who they are
At the centre
Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them.
Holds DL Derek LoweRead this korrent →
Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.
Holds AT Alex TelfordRT Ruxandra Teslo
Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time.
Holds DL Derek Lowe
Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.
Holds RT Ruxandra Teslo
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds AT Alex TelfordRT Ruxandra Teslo
How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly.
Holds AT Alex TelfordRT Ruxandra Teslo
Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be.
Holds RT Ruxandra Teslo
Because research is concentrated in rich countries, both what we know and what gets made are skewed away from the diseases of poor ones.
Holds JT Jacob Trefethen
A million copies of one researcher would hit diminishing returns quickly, because what research needs is people who think differently.
Holds IS Ilya Sutskever
"Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic".
Holds JS Jonathan Shedler
A prescriber cannot outsource containment to the therapy hour: the emotional and relational dynamics are part of prescribing, not an intrusion on it.
Holds AA Awais Aftab
Character is not fixed: therapy works because habitual neural pathways can re-form, sometimes within minutes.
Holds TR Terry Real
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Convergence and simplicity make for poor goals in technology; aim for clarity instead.
Holds FC Frank Chimero
Savings in time feel like simplicity: when forced to wait, life seems unnecessarily complex.
Holds JM John Maeda
Action comes before motivation: you do first and feel afterwards, not the other way round.
Holds LF Lex Fridman
No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often.
Holds JS Jonathan Shedler
A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work.
Holds SM Scott D. Miller