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← Drug discovery has become less efficient over time despite continued technological progress.
17 connected korrents · 15 moments from 8 Mar 2012 to 12 Aug 2026.
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design Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Drug discovery has become less efficient over time despite continued technological progress. Drug discovery has become less efficient over time despite continued technological progress. Last stated 8 months ago
18 Jan 2026
EH
Elliot Hershberg — holds since 2026-01-18 — tap for who they are
Same subject: Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. — tap to centre the map on it Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. — tap to centre the map on it Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: New technologies can meaningfully improve R&D productivity in drug development. — tap to centre the map on it New technologies can meaningfully improve R&D productivity in drug development. Last stated 6 months ago
12 Apr 2026
EH
Elliot Hershberg — holds since 2026-04-12 — tap for who they are
Same subject: Technology has made markets less efficient at long horizons rather than more efficient. — tap to centre the map on it Technology has made markets less efficient at long horizons rather than more efficient. Last stated 2 years ago
3 Sept 2024
CA
Cliff Asness — holds since 2024-09-03 — tap for who they are
Same subject: Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. — tap to centre the map on it Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: The stock market has become less informationally efficient over the past thirty-plus years, particularly in the relative pricing of common stocks over medium horizons. — tap to centre the map on it The stock market has become less informationally efficient over the past thirty-plus years, particularly in the relative pricing of common stocks over medium horizons. Last stated 2 years ago
3 Sept 2024
CA
Cliff Asness — holds since 2024-09-03 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. Last stated 7 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once. — tap to centre the map on it The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. — tap to centre the map on it A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. Last stated 2 years ago
13 May 2024
DL
Derek Lowe — holds since 2024-05-13 — tap for who they are
Same subject: A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck. — tap to centre the map on it A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck. Last stated 2 years ago
17 Sept 2024
AT
Alex Telford — holds since 2024-09-17 — tap for who they are
Same subject: A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. — tap to centre the map on it A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. — tap to centre the map on it Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points. — tap to centre the map on it AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points. Last stated 10 months ago
23 Nov 2025
EH
Elliot Hershberg — holds since 2025-11-23 — tap for who they are
Same subject: AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. — tap to centre the map on it AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: Biology models are smaller than language models only because there is less data, not because biology is simpler. — tap to centre the map on it Biology models are smaller than language models only because there is less data, not because biology is simpler. Last stated 4 months ago
10 Jun 2026
MZ
Mark Zuckerberg — holds since 2026-06-10 — tap for who they are
Same subject: In an intellectually dead research field, feeding AI decades of meaningless work only produces more meaningless output. — tap to centre the map on it In an intellectually dead research field, feeding AI decades of meaningless work only produces more meaningless output. Last stated 2 months ago
26 Jul 2026
PW
Peter Woit — holds since 2026-07-26 — tap for who they are
Same subject: Progress toward AI autonomously solving major open scientific problems requires first mastering the organization and presentation of established knowledge in long-form writing. — tap to centre the map on it Progress toward AI autonomously solving major open scientific problems requires first mastering the organization and presentation of established knowledge in long-form writing. Last stated 2 months ago
12 Aug 2026
NL
Nathan Lambert — holds since 2026-08-12 — tap for who they are
At the centre
Drug discovery has become less efficient over time despite continued technological progress.
Holds Read this korrent →
Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.
Holds
Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them.
Holds
New technologies can meaningfully improve R&D productivity in drug development.
Holds
Technology has made markets less efficient at long horizons rather than more efficient.
Holds
Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time.
Holds
The stock market has become less informationally efficient over the past thirty-plus years, particularly in the relative pricing of common stocks over medium horizons.
Holds
Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.
Holds
The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once.
Holds
A compound's AI origin story is not by itself a reason to expect it to do better in the clinic.
Holds
A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck.
Holds
A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known.
Holds
Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics.
Holds
AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points.
Holds
AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work.
Holds
Biology models are smaller than language models only because there is less data, not because biology is simpler.
Holds
In an intellectually dead research field, feeding AI decades of meaningless work only produces more meaningless output.
Holds
Progress toward AI autonomously solving major open scientific problems requires first mastering the organization and presentation of established knowledge in long-form writing.
Holds