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← AI will not produce a big breakthrough in biological understanding any…

17 connected korrents · 12 moments from 15 Jul 2021 to 22 Sept 2026.

Everything filed under AI and science AI and science Everything filed under protein structure prediction protein structure prediction Everything filed under mathematics mathematics Everything filed under recursive self-improvement recursive self-improvement Cannot both be trueSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subject Read this korrent: AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. AI will not produce a big breakthrough inbiological understanding any time soon,because biology has nothing like theclean, complete, high-quality data thatmade protein-structure prediction work. Last stated 2 years ago 19 Sept 2024 DL Derek Lowe — holds since 2024-09-19 — tap for who they are Cannot both be true: Understanding the biological machine is about five years away, not ten. — tap to centre the map on it Understanding the biological machineis about five years away, not ten. Last stated 7 months ago 23 Mar 2026 JH Jensen Huang — holds since 2026-03-23 — tap for who they are Same subject: Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence. — tap to centre the map on it Deep learning has effectively solvedthe problem of predicting aprotein's 3D structure from itssequence. Last stated a year ago 29 Jun 2025 EH Elliot Hershberg — holds since 2025-06-29 — tap for who they are Same subject: AI-assisted biological research still depends on physical wet-lab work that remains a necessary bottleneck for now. — tap to centre the map on it AI-assisted biological researchstill depends on physical wet-labwork that remains a necessarybottleneck for now. Last stated a month ago 16 Sept 2026 KJ Katelyn Jetelina — holds since 2026-09-16 — tap for who they are Same subject: Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. — tap to centre the map on it Biology keeps turning up wholeclasses of things nobody knewexisted, and that is what defeatsattempts to model it. Last stated 2 years ago 19 Sept 2024 DL Derek Lowe — holds since 2024-09-19 — tap for who they are Same subject: The AI research cycle from idea to experiment will likely soon be 10x faster, but that may not make researchers 10x more productive in the field's net understanding. — tap to centre the map on it The AI research cycle from idea toexperiment will likely soon be 10xfaster, but that may not makeresearchers 10x more productive inthe field's net understanding. Last stated a month ago 22 Sept 2026 NL Nathan Lambert — holds since 2026-09-22 — tap for who they are Same subject: Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from. — tap to centre the map on it Most proteins have no knownfunction, so there is no pile ofsolid data for a model to learn mostof cell biology from. Last stated 2 years ago 19 Sept 2024 DL Derek Lowe — holds since 2024-09-19 — tap for who they are Same subject: A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. — tap to centre the map on it A compound's AI origin story is notby itself a reason to expect it todo better in the clinic. Last stated 2 years ago 13 May 2024 DL Derek Lowe — holds since 2024-05-13 — tap for who they are Same subject: How much machine learning can help a biological problem is set by the quality of the data around that problem, not by the algorithms. — tap to centre the map on it How much machine learning can help abiological problem is set by thequality of the data around thatproblem, not by the algorithms. Last stated 2 years ago 19 Sept 2024 DL Derek Lowe — holds since 2024-09-19 — tap for who they are Same subject: Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. — tap to centre the map on it Contemporary physical andevolutionary structure-predictionapproaches fall far short ofexperimental accuracy without aclose experimental homologue,limiting biological utility. Last stated 5 years ago 15 Jul 2021 DH Demis Hassabis — holds since 2021-07-15 — tap for who they are Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model canbeat a general one inside its owndomain, as AlphaFold did, andmaterials science and chip designare next. Last stated 3 months ago 30 Jul 2026 JD Jeff Dean — holds since 2026-07-30 — tap for who they are Same subject: Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available. — tap to centre the map on it Existing protein structureprediction methods fall far short ofatomic accuracy when no homologousstructure is available. Last stated 5 years ago 15 Jul 2021 DH Demis Hassabis — holds since 2021-07-15 — tap for who they are Same subject: A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock. — tap to centre the map on it A persistently rising dividend yieldeventually forces capitalappreciation as the market reratesthe stock. Last stated 8 months ago 3 Mar 2026 SB Sanjay Bakshi — holds since 2026-03-03 — tap for who they are Same subject: A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved. — tap to centre the map on it A proof and an explanation aredifferent things, and a theorem canstay an unsolved expository problemlong after it is proved. Last stated 4 months ago 30 Jun 2026 GS Grant Sanderson — holds since 2026-06-30 — tap for who they are Same subject: A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent. — tap to centre the map on it A stream of AI-written papers withany error rate at all becomesinsufferable, because finding theerror costs more than the paper isworth even at ninety-nine percent. Last stated 4 months ago 30 Jun 2026 GS Grant Sanderson — holds since 2026-06-30 — tap for who they are Same subject: A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute. — tap to centre the map on it A ban on self-recursive improvementin AI models would create a bigincentive for some other parts ofthe world to invest a lot more incompute. Last stated a month ago 22 Sept 2026 TC Tyler Cowen — holds since 2026-09-22 — tap for who they are Same subject: AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started. — tap to centre the map on it AI is already inside the recursiveself-improvement loop — what thelabs have shipped in recent weeksshows the cycle has started. Last stated 3 months ago 3 Aug 2026 CP Chamath Palihapitiya — holds since 2026-08-03 — tap for who they are Same subject: AI research will be fully automated around 2030 or 2031, and AI will beat humans at essentially any job by about 2033. — tap to centre the map on it AI research will be fully automatedaround 2030 or 2031, and AI willbeat humans at essentially any jobby about 2033. Last stated 2 months ago 11 Aug 2026 RG Ryan Greenblatt — holds since 2026-08-11 — tap for who they are
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At the centre AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. Last stated 19 Sept 2024 · 2 years ago Holds Derek Lowe Read this korrent →