Tap a claim on the ring to put it at the centre.
← Most proteins have no known function, so there is no pile of solid…
17 connected korrents · 14 moments on record from 19 Sept 2024 to 18 Aug 2026.
Everything filed under AI and science
AI and science
Everything filed under design
design
Everything filed under LLMs
LLMs
Everything filed under simplicity
simplicity In tension Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from. Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
In tension: Understanding the biological machine is about five years away, not ten. — tap to centre the map on it Understanding the biological machine is about five years away, not ten. Last stated 6 months ago
23 Mar 2026
JH
Jensen Huang — holds since 2026-03-23 — tap for who they are
Same subject: Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. — tap to centre the map on it Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. — tap to centre the map on it AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: Biology models are smaller than language models only because there is less data, not because biology is simpler. — tap to centre the map on it Biology models are smaller than language models only because there is less data, not because biology is simpler. Last stated 3 months ago
10 Jun 2026
MZ
Mark Zuckerberg — holds since 2026-06-10 — tap for who they are
Same subject: Biology has already handed us an alien library: hundreds of millions of protein machines we do not understand and can only study one at a time. — tap to centre the map on it Biology has already handed us an alien library: hundreds of millions of protein machines we do not understand and can only study one at a time. Last stated 5 months ago
7 Apr 2026
MN
Michael Nielsen — holds since 2026-04-07 — tap for who they are
Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. Last stated a month ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Large language models are a bad way to do science, because they have been fed so much that nobody knows what they already knew. — tap to centre the map on it Large language models are a bad way to do science, because they have been fed so much that nobody knows what they already knew. Last stated 11 months ago
26 Sept 2025
RS
Richard Sutton — holds since 2025-09-26 — tap for who they are
Same subject: Anything nature shaped can be learned efficiently by a classical neural network, because evolutionary processes leave structure behind. — tap to centre the map on it Anything nature shaped can be learned efficiently by a classical neural network, because evolutionary processes leave structure behind. Last stated a year ago
23 Jul 2025
DH
Demis Hassabis — holds since 2025-07-23 — tap for who they are
Same subject: There is no factory you can pay to produce biological data; each new dataset requires inventing a new scientific method first. — tap to centre the map on it There is no factory you can pay to produce biological data; each new dataset requires inventing a new scientific method first. Last stated 3 months ago
10 Jun 2026
MZ
Mark Zuckerberg — holds since 2026-06-10 — tap for who they are
Same subject: AI could compete with human mathematicians once it acquires a mathematical sense of smell: knowing which way of splitting a problem makes it easier rather than harder. — tap to centre the map on it AI could compete with human mathematicians once it acquires a mathematical sense of smell: knowing which way of splitting a problem makes it easier rather than harder. Last stated a year ago
14 Jun 2025
TT
Terence Tao — holds since 2025-06-14 — tap for who they are
Same subject: AI in chess and mathematics does not explain anything; it says which position is better, and humans build the theory from that. — tap to centre the map on it AI in chess and mathematics does not explain anything; it says which position is better, and humans build the theory from that. Last stated a year ago
14 Jun 2025
LF
Lex Fridman — holds since 2025-06-14 — tap for who they are
Same subject: AI will transform how scientific discovery is done, and within two or three years a working scientist's job will already look dramatically different. — tap to centre the map on it AI will transform how scientific discovery is done, and within two or three years a working scientist's job will already look dramatically different. Last stated 3 weeks ago
18 Aug 2026
MK
Michael Kratsios — holds since 2026-08-18 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. — tap to centre the map on it A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. Last stated a year ago
23 Mar 2025
RV
Rahul Vohra — holds since 2025-03-23 — tap for who they are
Same subject: A computer meant for anyone has to be understandable without a manual, and it has to be friendly. — tap to centre the map on it A computer meant for anyone has to be understandable without a manual, and it has to be friendly. Last stated 3 weeks ago
14 Aug 2026
SK
Susan Kare — holds since 2026-08-14 — tap for who they are
Same subject: After a decade of Swiss minimalism, design is about to swing back to something far more expressive. — tap to centre the map on it After a decade of Swiss minimalism, design is about to swing back to something far more expressive. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
At the centre
Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from.
Holds DL Derek LoweRead this korrent →
Understanding the biological machine is about five years away, not ten.
Holds JH Jensen Huang
Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it.
Holds DL Derek Lowe
AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work.
Holds DL Derek Lowe
Biology models are smaller than language models only because there is less data, not because biology is simpler.
Holds MZ Mark Zuckerberg
Biology has already handed us an alien library: hundreds of millions of protein machines we do not understand and can only study one at a time.
Holds MN Michael Nielsen
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Holds JD Jeff Dean
Large language models are a bad way to do science, because they have been fed so much that nobody knows what they already knew.
Holds RS Richard Sutton
Anything nature shaped can be learned efficiently by a classical neural network, because evolutionary processes leave structure behind.
Holds DH Demis Hassabis
There is no factory you can pay to produce biological data; each new dataset requires inventing a new scientific method first.
Holds MZ Mark Zuckerberg
AI could compete with human mathematicians once it acquires a mathematical sense of smell: knowing which way of splitting a problem makes it easier rather than harder.
Holds TT Terence Tao
AI in chess and mathematics does not explain anything; it says which position is better, and humans build the theory from that.
Holds LF Lex Fridman
AI will transform how scientific discovery is done, and within two or three years a working scientist's job will already look dramatically different.
Holds MK Michael Kratsios
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds JZ Julie Zhuo
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Holds RV Rahul Vohra
A computer meant for anyone has to be understandable without a manual, and it has to be friendly.
Holds SK Susan Kare
After a decade of Swiss minimalism, design is about to swing back to something far more expressive.
Holds DF Dylan Field
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds