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← Most proteins have no known function, so there is no pile of solid…
17 connected korrents · 15 moments from 15 Jul 2021 to 22 Sept 2026.
Everything filed under AI and science
AI and science
Everything filed under mathematics
mathematics
Everything filed under recursive self-improvement
recursive self-improvement
Everything filed under protein structure prediction
protein structure prediction
Everything filed under innovation
innovation
Everything filed under LLMs
LLMs In tension Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from. Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
In tension: Understanding the biological machine is about five years away, not ten. — tap to centre the map on it Understanding the biological machine is about five years away, not ten. Last stated 7 months ago
23 Mar 2026
JH
Jensen Huang — holds since 2026-03-23 — tap for who they are
Same subject: Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. — tap to centre the map on it Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. — tap to centre the map on it AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: Biology models are smaller than language models only because there is less data, not because biology is simpler. — tap to centre the map on it Biology models are smaller than language models only because there is less data, not because biology is simpler. Last stated 4 months ago
10 Jun 2026
MZ
Mark Zuckerberg — holds since 2026-06-10 — tap for who they are
Same subject: Biology has already handed us an alien library: hundreds of millions of protein machines we do not understand and can only study one at a time. — tap to centre the map on it Biology has already handed us an alien library: hundreds of millions of protein machines we do not understand and can only study one at a time. Last stated 7 months ago
7 Apr 2026
MN
Michael Nielsen — holds since 2026-04-07 — tap for who they are
Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. Last stated 3 months ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Large language models are a bad way to do science, because they have been fed so much that nobody knows what they already knew. — tap to centre the map on it Large language models are a bad way to do science, because they have been fed so much that nobody knows what they already knew. Last stated a year ago
26 Sept 2025
RS
Richard Sutton — holds since 2025-09-26 — tap for who they are
Same subject: Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available. — tap to centre the map on it Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli. — tap to centre the map on it Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli. Last stated a year ago
29 Jun 2025
EH
Elliot Hershberg — holds since 2025-06-29 — tap for who they are
Same subject: A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock. — tap to centre the map on it A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock. Last stated 8 months ago
3 Mar 2026
SB
Sanjay Bakshi — holds since 2026-03-03 — tap for who they are
Same subject: A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved. — tap to centre the map on it A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved. Last stated 4 months ago
30 Jun 2026
GS
Grant Sanderson — holds since 2026-06-30 — tap for who they are
Same subject: A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent. — tap to centre the map on it A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent. Last stated 4 months ago
30 Jun 2026
GS
Grant Sanderson — holds since 2026-06-30 — tap for who they are
Same subject: A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute. — tap to centre the map on it A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute. Last stated a month ago
22 Sept 2026
TC
Tyler Cowen — holds since 2026-09-22 — tap for who they are
Same subject: AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started. — tap to centre the map on it AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started. Last stated 3 months ago
3 Aug 2026
CP
Chamath Palihapitiya — holds since 2026-08-03 — tap for who they are
Same subject: AI research will be fully automated around 2030 or 2031, and AI will beat humans at essentially any job by about 2033. — tap to centre the map on it AI research will be fully automated around 2030 or 2031, and AI will beat humans at essentially any job by about 2033. Last stated 2 months ago
11 Aug 2026
RG
Ryan Greenblatt — holds since 2026-08-11 — tap for who they are
Same subject: "Lots of anonymous people worked it out by trial and error" is never the real story of an invention: on closer investigation, identifiable people always turn out to be responsible. — tap to centre the map on it "Lots of anonymous people worked it out by trial and error" is never the real story of an invention: on closer investigation, identifiable people always turn out to be responsible. Last stated 3 years ago
25 Oct 2023
AH
Anton Howes — holds since 2023-10-25 — tap for who they are
Same subject: A business can have market fit, real advantages, and sustained effort behind a hard product and still fail if it doesn't give customers a strong enough reason to switch from what they already use. — tap to centre the map on it A business can have market fit, real advantages, and sustained effort behind a hard product and still fail if it doesn't give customers a strong enough reason to switch from what they already use. Last stated 5 months ago
2 Jun 2026
JJ
Justin Jackson — holds since 2026-06-02 — tap for who they are
At the centre
Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from.
Holds Read this korrent →
Understanding the biological machine is about five years away, not ten.
Holds
Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it.
Holds
AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work.
Holds
Biology models are smaller than language models only because there is less data, not because biology is simpler.
Holds
Biology has already handed us an alien library: hundreds of millions of protein machines we do not understand and can only study one at a time.
Holds
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Holds
Large language models are a bad way to do science, because they have been fed so much that nobody knows what they already knew.
Holds
Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available.
Holds
Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli.
Holds
A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock.
Holds
A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved.
Holds
A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent.
Holds
A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute.
Holds
AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started.
Holds
AI research will be fully automated around 2030 or 2031, and AI will beat humans at essentially any job by about 2033.
Holds
"Lots of anonymous people worked it out by trial and error" is never the real story of an invention: on closer investigation, identifiable people always turn out to be responsible.
Holds
A business can have market fit, real advantages, and sustained effort behind a hard product and still fail if it doesn't give customers a strong enough reason to switch from what they already use.
Holds