17 connected korrents · 17 moments from 8 Jan 2013 to 4 Oct 2026.
At the centre
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Last stated 30 Jul 2026 · 3 months ago
Holds
Jeff Dean
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Same subject: protein structure prediction
Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence.
Last stated 29 Jun 2025 · a year ago
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Elliot Hershberg
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Same subject: protein structure prediction
Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available.
Last stated 15 Jul 2021 · 5 years ago
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Demis Hassabis
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Same subject: protein structure prediction
We have not scratched the surface of what classical, non-quantum computers can do; they can already go far further than anyone expected.
Last stated 23 Jul 2025 · a year ago
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Demis Hassabis
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Same subject: design
A baby-step version of eval-driven design is to sketch out 10 to 20 hero flows and run the feature or interaction through them to see where it falls apart.
Last stated 9 Sept 2026 · a month ago
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Ed Bayes
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Same subject: design
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Last stated 12 May 2025 · a year ago
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Julie Zhuo
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Same subject: design
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Last stated 23 Mar 2025 · 2 years ago
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Rahul Vohra
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Same subject: design
A company hiring a designer is not hiring a politician or spokesperson, so it should just get into the design work.
Last stated 29 Sept 2026 · 3 weeks ago
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Danny Martinez
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Same subject: design
A company that adopts AI tools without changing its organisational design misses the biggest change under way.
Last stated 10 Sept 2026 · a month ago
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Elena Verna
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Same subject: simplicity
A business is more likely to fail from taking on too much complexity than from lacking resources.
Last stated 29 Sept 2018 · 8 years ago
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Tren Griffin
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Same subject: simplicity
A business succeeds through a small number of highly effective distribution channels, not many mediocre ones.
Last stated 17 Feb 2024 · 3 years ago
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Adam Wiggins
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Same subject: simplicity
A candidate negotiating an offer should make every ask fit one line of logic.
Last stated 9 Aug 2026 · 2 months ago
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Adam Ward
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Same subject: taste
A big part of taste is delivering high levels of craft in an accessible way so that as many people as possible can experience it.
Last stated 21 Apr 2026 · 6 months ago
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Brandon Jacoby
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Same subject: taste
A company name can have different appeal to corporate buyers versus their customers.
Last stated 4 Oct 2026 · 3 weeks ago
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Paul Graham
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Same subject: taste
A first draft should not be graded good or bad; it is only the material that taste then gets to act on.
Last stated 6 Aug 2026 · 3 months ago
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George Saunders
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Same subject: creativity
A feeling of responsibility is probably the greatest inhibitor of creativity; great ideas came from people not paid to have them
Last stated c. 1959
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Isaac Asimov
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Same subject: creativity
A free-wheeling, anarchic neural organization may be the secret of human creativity, at the price of susceptibility to mental illness
Last stated 8 Jan 2013 · 14 years ago
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Daniel Dennett
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Same subject: creativity
A person who works from a recipe, even an innovative one, starts from something that already exists.
Last stated 6 Nov 2015 · 11 years ago
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Tim Urban