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← Contemporary physical and evolutionary structure-prediction approaches…
17 connected korrents · 12 moments on record from 15 Jul 2021 to 14 Aug 2026.
Everything filed under design
design
Everything filed under taste
taste
Everything filed under protein structure prediction
protein structure prediction
Everything filed under simplicity
simplicity Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available. — tap to centre the map on it Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. — tap to centre the map on it A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. Last stated a month ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. — tap to centre the map on it AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. — tap to centre the map on it Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. — tap to centre the map on it Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: Bacteria never became complex because the barrier is structure, not information — they explored genetic space far more thoroughly than eukaryotes and still got stuck. — tap to centre the map on it Bacteria never became complex because the barrier is structure, not information — they explored genetic space far more thoroughly than eukaryotes and still got stuck. Last stated 4 years ago
7 Sept 2022
NL
Nick Lane — holds since 2022-09-07 — tap for who they are
Same subject: How much machine learning can help a biological problem is set by the quality of the data around that problem, not by the algorithms. — tap to centre the map on it How much machine learning can help a biological problem is set by the quality of the data around that problem, not by the algorithms. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. — tap to centre the map on it A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. Last stated a year ago
23 Mar 2025
RV
Rahul Vohra — holds since 2025-03-23 — tap for who they are
Same subject: A computer meant for anyone has to be understandable without a manual, and it has to be friendly. — tap to centre the map on it A computer meant for anyone has to be understandable without a manual, and it has to be friendly. Last stated 4 weeks ago
14 Aug 2026
SK
Susan Kare — holds since 2026-08-14 — tap for who they are
Same subject: After a decade of Swiss minimalism, design is about to swing back to something far more expressive. — tap to centre the map on it After a decade of Swiss minimalism, design is about to swing back to something far more expressive. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated 2 months ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Better design does not mean more design: the most obvious designs are often invisible. — tap to centre the map on it Better design does not mean more design: the most obvious designs are often invisible. Last stated 3 years ago
16 Nov 2023
JZ
Julie Zhuo — holds since 2023-11-16 — tap for who they are
Same subject: A first draft should not be graded good or bad; it is only the material that taste then gets to act on. — tap to centre the map on it A first draft should not be graded good or bad; it is only the material that taste then gets to act on. Last stated a month ago
6 Aug 2026
GS
George Saunders — holds since 2026-08-06 — tap for who they are
Same subject: A gift's perceived price is part of what it does, so a drink known to be cheap fails at its job however good it tastes. — tap to centre the map on it A gift's perceived price is part of what it does, so a drink known to be cheap fails at its job however good it tastes. Last stated 9 months ago
9 Dec 2025
RS
Rory Sutherland — holds since 2025-12-09 — tap for who they are
Same subject: A lot of people can match a framework for taste; almost nobody can create one, and creating one is the rare skill. — tap to centre the map on it A lot of people can match a framework for taste; almost nobody can create one, and creating one is the rare skill. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
At the centre
Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility.
Holds DH Demis HassabisRead this korrent →
Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available.
Holds DH Demis Hassabis
A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known.
Holds DH Demis Hassabis
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Holds JD Jeff Dean
AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work.
Holds DL Derek Lowe
Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics.
Holds DH Demis Hassabis
Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it.
Holds DL Derek Lowe
Bacteria never became complex because the barrier is structure, not information — they explored genetic space far more thoroughly than eukaryotes and still got stuck.
Holds NL Nick Lane
How much machine learning can help a biological problem is set by the quality of the data around that problem, not by the algorithms.
Holds DL Derek Lowe
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds JZ Julie Zhuo
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Holds RV Rahul Vohra
A computer meant for anyone has to be understandable without a manual, and it has to be friendly.
Holds SK Susan Kare
After a decade of Swiss minimalism, design is about to swing back to something far more expressive.
Holds DF Dylan Field
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Better design does not mean more design: the most obvious designs are often invisible.
Holds JZ Julie Zhuo
A first draft should not be graded good or bad; it is only the material that taste then gets to act on.
Holds GS George Saunders
A gift's perceived price is part of what it does, so a drink known to be cheap fails at its job however good it tastes.
Holds RS Rory Sutherland
A lot of people can match a framework for taste; almost nobody can create one, and creating one is the rare skill.
Holds DF Dylan Field