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← About ninety per cent of drugs that enter clinical trials fail.
13 connected korrents · 14 moments on record from 8 Mar 2012 to 18 Aug 2026.
Everything filed under AI and science
AI and science
Everything filed under design
design
Everything filed under simplicity
simplicity In tension Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: About ninety per cent of drugs that enter clinical trials fail. About ninety per cent of drugs that enter clinical trials fail. Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
In tension: Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years. — tap to centre the map on it Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years. Last stated 2 years ago
1 Oct 2024
DA
Dario Amodei — holds since 2024-10-01 — tap for who they are
Same subject: Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. — tap to centre the map on it Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. — tap to centre the map on it Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: AI could compete with human mathematicians once it acquires a mathematical sense of smell: knowing which way of splitting a problem makes it easier rather than harder. — tap to centre the map on it AI could compete with human mathematicians once it acquires a mathematical sense of smell: knowing which way of splitting a problem makes it easier rather than harder. Last stated a year ago
14 Jun 2025
TT
Terence Tao — holds since 2025-06-14 — tap for who they are
Same subject: AI in chess and mathematics does not explain anything; it says which position is better, and humans build the theory from that. — tap to centre the map on it AI in chess and mathematics does not explain anything; it says which position is better, and humans build the theory from that. Last stated a year ago
14 Jun 2025
LF
Lex Fridman — holds since 2025-06-14 — tap for who they are
Same subject: AI will transform how scientific discovery is done, and within two or three years a working scientist's job will already look dramatically different. — tap to centre the map on it AI will transform how scientific discovery is done, and within two or three years a working scientist's job will already look dramatically different. Last stated 3 weeks ago
18 Aug 2026
MK
Michael Kratsios — holds since 2026-08-18 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. — tap to centre the map on it A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. Last stated a year ago
23 Mar 2025
RV
Rahul Vohra — holds since 2025-03-23 — tap for who they are
Same subject: A computer meant for anyone has to be understandable without a manual, and it has to be friendly. — tap to centre the map on it A computer meant for anyone has to be understandable without a manual, and it has to be friendly. Last stated 4 weeks ago
14 Aug 2026
SK
Susan Kare — holds since 2026-08-14 — tap for who they are
Same subject: After a decade of Swiss minimalism, design is about to swing back to something far more expressive. — tap to centre the map on it After a decade of Swiss minimalism, design is about to swing back to something far more expressive. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Better design does not mean more design: the most obvious designs are often invisible. — tap to centre the map on it Better design does not mean more design: the most obvious designs are often invisible. Last stated 3 years ago
16 Nov 2023
JZ
Julie Zhuo — holds since 2023-11-16 — tap for who they are
At the centre
About ninety per cent of drugs that enter clinical trials fail.
Holds RT Ruxandra TesloDL Derek LoweRead this korrent →
Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years.
Holds DA Dario Amodei
Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.
Holds AT Alex TelfordRT Ruxandra Teslo
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds AT Alex TelfordRT Ruxandra Teslo
Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them.
Holds DL Derek Lowe
AI could compete with human mathematicians once it acquires a mathematical sense of smell: knowing which way of splitting a problem makes it easier rather than harder.
Holds TT Terence Tao
AI in chess and mathematics does not explain anything; it says which position is better, and humans build the theory from that.
Holds LF Lex Fridman
AI will transform how scientific discovery is done, and within two or three years a working scientist's job will already look dramatically different.
Holds MK Michael Kratsios
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds JZ Julie Zhuo
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Holds RV Rahul Vohra
A computer meant for anyone has to be understandable without a manual, and it has to be friendly.
Holds SK Susan Kare
After a decade of Swiss minimalism, design is about to swing back to something far more expressive.
Holds DF Dylan Field
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Better design does not mean more design: the most obvious designs are often invisible.
Holds JZ Julie Zhuo