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← About ninety per cent of drugs that enter clinical trials fail.
13 connected korrents · 14 moments from 8 Mar 2012 to 17 Sept 2026.
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design
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design In tension Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: About ninety per cent of drugs that enter clinical trials fail. About ninety per cent of drugs that enter clinical trials fail. Last stated 8 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
In tension: Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years. — tap to centre the map on it Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years. Last stated 2 years ago
1 Oct 2024
DA
Dario Amodei — holds since 2024-10-01 — tap for who they are
Same subject: Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. — tap to centre the map on it Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. Last stated 3 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 3 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. — tap to centre the map on it Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. Last stated 15 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. — tap to centre the map on it A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. Last stated 2 years ago
13 May 2024
DL
Derek Lowe — holds since 2024-05-13 — tap for who they are
Same subject: A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck. — tap to centre the map on it A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck. Last stated 2 years ago
17 Sept 2024
AT
Alex Telford — holds since 2024-09-17 — tap for who they are
Same subject: A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. — tap to centre the map on it A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. Last stated 3 months ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. — tap to centre the map on it Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points. — tap to centre the map on it AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points. Last stated 11 months ago
23 Nov 2025
EH
Elliot Hershberg — holds since 2025-11-23 — tap for who they are
Same subject: A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI. — tap to centre the map on it A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI. Last stated 10 months ago
1 Jan 2026
JL
Jason Lemkin — holds since 2026-01-01 — tap for who they are
Same subject: A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to. — tap to centre the map on it A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to. Last stated 3 months ago
15 Jul 2026
DH
Dex Horthy — holds since 2026-07-15 — tap for who they are
Same subject: A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls. — tap to centre the map on it A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls. Last stated a month ago
17 Sept 2026
PC
Patrick Collison — holds since 2026-09-17 — tap for who they are
At the centre
About ninety per cent of drugs that enter clinical trials fail.
Holds Read this korrent →
Powerful AI will compress the biological and medical progress of the next 50-100 years into 5-10 years.
Holds
Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.
Holds
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds
Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them.
Holds
A compound's AI origin story is not by itself a reason to expect it to do better in the clinic.
Holds
A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck.
Holds
A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known.
Holds
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Holds
Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics.
Holds
AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points.
Holds
A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI.
Holds
A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to.
Holds
A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls.
Holds