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← The drugs advertised as having AI-discovered targets are aimed at targets people already knew about.

17 connected korrents · 15 moments from 15 Jul 2021 to 22 Sept 2026.

Everything filed under AI and science AI and science Everything filed under mathematics mathematics Everything filed under protein structure prediction protein structure prediction Everything filed under AI alignment AI alignment Everything filed under LLMs LLMs Everything filed under recursive self-improvement recursive self-improvement In tensionSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subject Read this korrent: The drugs advertised as having AI-discovered targets are aimed at targets people already knew about. The drugs advertised as havingAI-discovered targets are aimed at targetspeople already knew about. Last stated 2 years ago 13 May 2024 DL Derek Lowe — holds since 2024-05-13 — tap for who they are In tension: Research by the author and colleagues found that AI models generate more commercially viable ideas than groups of humans, but those ideas are very similar. — tap to centre the map on it Research by the author andcolleagues found that AI modelsgenerate more commercially viableideas than groups of humans, butthose ideas are very similar. Last stated 2 months ago 31 Aug 2026 EM Ethan Mollick — holds since 2026-08-31 — tap for who they are Same subject: A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. — tap to centre the map on it A compound's AI origin story is notby itself a reason to expect it todo better in the clinic. Last stated 2 years ago 13 May 2024 DL Derek Lowe — holds since 2024-05-13 — tap for who they are Same subject: AI is being used to scam the public in science and academic communication. — tap to centre the map on it AI is being used to scam the publicin science and academiccommunication. Last stated 2 months ago 16 Aug 2026 PW Peter Woit — holds since 2026-08-16 — tap for who they are Same subject: We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often. — tap to centre the map on it We have neither the data nor theinsight to use machine learning topick drug targets that succeed inthe clinic more often. Last stated 3 years ago 25 May 2023 DL Derek Lowe — holds since 2023-05-25 — tap for who they are Same subject: Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. — tap to centre the map on it Drug companies pile onto the samefew already-validated targets, sofar less of biology gets exploredthan could be. Last stated 3 months ago 21 Jul 2026 RT Ruxandra Teslo — holds since 2026-07-21 — tap for who they are Same subject: No AI system today reduces either of the two risks that sink most drugs in the clinic: picking the wrong target, and human toxicity. — tap to centre the map on it No AI system today reduces either ofthe two risks that sink most drugsin the clinic: picking the wrongtarget, and human toxicity. Last stated 3 years ago 25 May 2023 DL Derek Lowe — holds since 2023-05-25 — tap for who they are Same subject: People should be more worried about AI bioweapons than they currently are. — tap to centre the map on it People should be more worried aboutAI bioweapons than they currentlyare. Last stated a month ago 10 Sept 2026 NS Noah Smith — holds since 2026-09-10 — tap for who they are Same subject: OpenAI's bots knew about a known security vulnerability and attempted to exploit it. — tap to centre the map on it OpenAI's bots knew about a knownsecurity vulnerability and attemptedto exploit it. Last stated a month ago 12 Sept 2026 AP Aaron Patterson — holds since 2026-09-12 — tap for who they are Same subject: The AI agents we send in to investigate and monitor other AI systems will collude with the systems they are supposed to be watching. — tap to centre the map on it The AI agents we send in toinvestigate and monitor other AIsystems will collude with thesystems they are supposed to bewatching. Last stated 2 months ago 1 Sept 2026 AC Ajeya Cotra — holds since 2026-09-01 — tap for who they are Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model canbeat a general one inside its owndomain, as AlphaFold did, andmaterials science and chip designare next. Last stated 3 months ago 30 Jul 2026 JD Jeff Dean — holds since 2026-07-30 — tap for who they are Same subject: Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. — tap to centre the map on it Contemporary physical andevolutionary structure-predictionapproaches fall far short ofexperimental accuracy without aclose experimental homologue,limiting biological utility. Last stated 5 years ago 15 Jul 2021 DH Demis Hassabis — holds since 2021-07-15 — tap for who they are Same subject: Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence. — tap to centre the map on it Deep learning has effectively solvedthe problem of predicting aprotein's 3D structure from itssequence. Last stated a year ago 29 Jun 2025 EH Elliot Hershberg — holds since 2025-06-29 — tap for who they are Same subject: A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock. — tap to centre the map on it A persistently rising dividend yieldeventually forces capitalappreciation as the market reratesthe stock. Last stated 8 months ago 3 Mar 2026 SB Sanjay Bakshi — holds since 2026-03-03 — tap for who they are Same subject: A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved. — tap to centre the map on it A proof and an explanation aredifferent things, and a theorem canstay an unsolved expository problemlong after it is proved. Last stated 4 months ago 30 Jun 2026 GS Grant Sanderson — holds since 2026-06-30 — tap for who they are Same subject: A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent. — tap to centre the map on it A stream of AI-written papers withany error rate at all becomesinsufferable, because finding theerror costs more than the paper isworth even at ninety-nine percent. Last stated 4 months ago 30 Jun 2026 GS Grant Sanderson — holds since 2026-06-30 — tap for who they are Same subject: A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute. — tap to centre the map on it A ban on self-recursive improvementin AI models would create a bigincentive for some other parts ofthe world to invest a lot more incompute. Last stated a month ago 22 Sept 2026 TC Tyler Cowen — holds since 2026-09-22 — tap for who they are Same subject: AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started. — tap to centre the map on it AI is already inside the recursiveself-improvement loop — what thelabs have shipped in recent weeksshows the cycle has started. Last stated 3 months ago 3 Aug 2026 CP Chamath Palihapitiya — holds since 2026-08-03 — tap for who they are
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At the centre The drugs advertised as having AI-discovered targets are aimed at targets people already knew about. Last stated 13 May 2024 · 2 years ago Holds Derek Lowe Read this korrent →