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← Having a biochemical pathway does not mean something will produce an…
17 connected korrents · 16 moments from 3 Jul 2013 to 17 Sept 2026.
Everything filed under innovation
innovation
Everything filed under protein structure prediction
protein structure prediction
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LLMs
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AI and science
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energy Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Having a biochemical pathway does not mean something will produce an outcome, though any real outcome has a mechanism behind it. Having a biochemical pathway does not mean something will produce an outcome, though any real outcome has a mechanism behind it. Last stated 2 years ago
12 Aug 2024
LN
Layne Norton — holds since 2024-08-12 — tap for who they are
Same subject: Biological self-organisation is less remarkable than it seems, and almost inevitable given local interactions. — tap to centre the map on it Biological self-organisation is less remarkable than it seems, and almost inevitable given local interactions. Last stated 13 years ago
3 Jul 2013
KF
Karl Friston — holds since 2013-07-03 — tap for who they are
Same subject: The causes of an outcome cannot be divided into slices that add up to 100 per cent, so a large effect from one cause does not leave a small remainder for the others. — tap to centre the map on it The causes of an outcome cannot be divided into slices that add up to 100 per cent, so a large effect from one cause does not leave a small remainder for the others. Last stated a year ago
24 Apr 2025
SD
Saloni Dattani — holds since 2025-04-24 — tap for who they are
Same subject: Scientific progress in biology is not slowing down. — tap to centre the map on it Scientific progress in biology is not slowing down. Last stated 7 years ago
15 Aug 2019
AG
Alexey Guzey — holds since 2019-08-15 — tap for who they are
Same subject: Unlike physics, biology's complexity and nonlinearity make a brute-force approach to knowledge creation necessary rather than one based on writing down equations. — tap to centre the map on it Unlike physics, biology's complexity and nonlinearity make a brute-force approach to knowledge creation necessary rather than one based on writing down equations. Last stated a year ago
29 Jun 2025
EH
Elliot Hershberg — holds since 2025-06-29 — tap for who they are
Same subject: Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli. — tap to centre the map on it Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli. Last stated a year ago
29 Jun 2025
EH
Elliot Hershberg — holds since 2025-06-29 — tap for who they are
Same subject: A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. — tap to centre the map on it A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. Last stated 2 years ago
13 May 2024
DL
Derek Lowe — holds since 2024-05-13 — tap for who they are
Same subject: The hardest step on the road from chemistry to us was multicellularity, and it was strictly a problem of energetics. — tap to centre the map on it The hardest step on the road from chemistry to us was multicellularity, and it was strictly a problem of energetics. Last stated a year ago
5 May 2025
JL
Janna Levin — holds since 2025-05-05 — tap for who they are
Same subject: AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. — tap to centre the map on it AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: "Lots of anonymous people worked it out by trial and error" is never the real story of an invention: on closer investigation, identifiable people always turn out to be responsible. — tap to centre the map on it "Lots of anonymous people worked it out by trial and error" is never the real story of an invention: on closer investigation, identifiable people always turn out to be responsible. Last stated 3 years ago
25 Oct 2023
AH
Anton Howes — holds since 2023-10-25 — tap for who they are
Same subject: A business can have market fit, real advantages, and sustained effort behind a hard product and still fail if it doesn't give customers a strong enough reason to switch from what they already use. — tap to centre the map on it A business can have market fit, real advantages, and sustained effort behind a hard product and still fail if it doesn't give customers a strong enough reason to switch from what they already use. Last stated 4 months ago
2 Jun 2026
JJ
Justin Jackson — holds since 2026-06-02 — tap for who they are
Same subject: A capability existing is not the same as a capability being absorbed: how fast a technology changes the world is not set by how fast the technology improves. — tap to centre the map on it A capability existing is not the same as a capability being absorbed: how fast a technology changes the world is not set by how fast the technology improves. Last stated 3 months ago
21 Jul 2026
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. Last stated 2 months ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. — tap to centre the map on it Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence. — tap to centre the map on it Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence. Last stated a year ago
29 Jun 2025
EH
Elliot Hershberg — holds since 2025-06-29 — tap for who they are
Same subject: A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI. — tap to centre the map on it A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI. Last stated 9 months ago
1 Jan 2026
JL
Jason Lemkin — holds since 2026-01-01 — tap for who they are
Same subject: A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to. — tap to centre the map on it A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to. Last stated 3 months ago
15 Jul 2026
DH
Dex Horthy — holds since 2026-07-15 — tap for who they are
Same subject: A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls. — tap to centre the map on it A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls. Last stated 3 weeks ago
17 Sept 2026
PC
Patrick Collison — holds since 2026-09-17 — tap for who they are
At the centre
Having a biochemical pathway does not mean something will produce an outcome, though any real outcome has a mechanism behind it.
Holds Read this korrent →
Biological self-organisation is less remarkable than it seems, and almost inevitable given local interactions.
Holds
The causes of an outcome cannot be divided into slices that add up to 100 per cent, so a large effect from one cause does not leave a small remainder for the others.
Holds
Scientific progress in biology is not slowing down.
Holds
Unlike physics, biology's complexity and nonlinearity make a brute-force approach to knowledge creation necessary rather than one based on writing down equations.
Holds
Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli.
Holds
A compound's AI origin story is not by itself a reason to expect it to do better in the clinic.
Holds
The hardest step on the road from chemistry to us was multicellularity, and it was strictly a problem of energetics.
Holds
AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work.
Holds
"Lots of anonymous people worked it out by trial and error" is never the real story of an invention: on closer investigation, identifiable people always turn out to be responsible.
Holds
A business can have market fit, real advantages, and sustained effort behind a hard product and still fail if it doesn't give customers a strong enough reason to switch from what they already use.
Holds
A capability existing is not the same as a capability being absorbed: how fast a technology changes the world is not set by how fast the technology improves.
Holds
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Holds
Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility.
Holds
Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence.
Holds
A badly written AI outbound email is evidence of a bad vendor, not of a limit of AI.
Holds
A bigger context window does not give you a smarter model; the intelligence of the model is what decides how much of that window it can actually attend to.
Holds
A body of publications is easy for AI models to consume via pretraining corpora but cumbersome for most humans due to CAPTCHAs, accounts, and paywalls.
Holds