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← Biological self-organisation is less remarkable than it seems, and almost inevitable given local interactions.
17 connected korrents · 13 moments from 3 Jul 2013 to 22 Sept 2026.
Everything filed under protein structure prediction
protein structure prediction
Everything filed under mathematics
mathematics
Everything filed under recursive self-improvement
recursive self-improvement
Everything filed under infrastructure
infrastructure
Everything filed under AI and science
AI and science
Everything filed under physics
physics
Everything filed under LLMs
LLMs Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Biological self-organisation is less remarkable than it seems, and almost inevitable given local interactions. Biological self-organisation is less remarkable than it seems, and almost inevitable given local interactions. Last stated 13 years ago
3 Jul 2013
KF
Karl Friston — holds since 2013-07-03 — tap for who they are
Same subject: Life may be an inevitable, emergent property of any random dynamical system with a Markov blanket. — tap to centre the map on it Life may be an inevitable, emergent property of any random dynamical system with a Markov blanket. Last stated 13 years ago
3 Jul 2013
KF
Karl Friston — holds since 2013-07-03 — tap for who they are
Same subject: Any ergodic system with a Markov blanket will almost surely behave in lifelike ways; nothing suggests a special role for carbon. — tap to centre the map on it Any ergodic system with a Markov blanket will almost surely behave in lifelike ways; nothing suggests a special role for carbon. Last stated 13 years ago
3 Jul 2013
KF
Karl Friston — holds since 2013-07-03 — tap for who they are
Same subject: AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. — tap to centre the map on it AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: Making a change within a complex system tends to produce unforeseen and unintended consequences. — tap to centre the map on it Making a change within a complex system tends to produce unforeseen and unintended consequences. Last stated 4 years ago
30 May 2022
SC
Steve Coast — holds since 2022-05-30 — tap for who they are
Same subject: Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. — tap to centre the map on it Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. Last stated 2 years ago
19 Sept 2024
DL
Derek Lowe — holds since 2024-09-19 — tap for who they are
Same subject: Having a biochemical pathway does not mean something will produce an outcome, though any real outcome has a mechanism behind it. — tap to centre the map on it Having a biochemical pathway does not mean something will produce an outcome, though any real outcome has a mechanism behind it. Last stated 2 years ago
12 Aug 2024
LN
Layne Norton — holds since 2024-08-12 — tap for who they are
Same subject: Unlike physics, biology's complexity and nonlinearity make a brute-force approach to knowledge creation necessary rather than one based on writing down equations. — tap to centre the map on it Unlike physics, biology's complexity and nonlinearity make a brute-force approach to knowledge creation necessary rather than one based on writing down equations. Last stated a year ago
29 Jun 2025
EH
Elliot Hershberg — holds since 2025-06-29 — tap for who they are
Same subject: Change from already-capable AI is inevitable no matter how the frontier is paced, though it will be uneven and not all at once. — tap to centre the map on it Change from already-capable AI is inevitable no matter how the frontier is paced, though it will be uneven and not all at once. Last stated 3 weeks ago
18 Sept 2026
EM
Ethan Mollick — holds since 2026-09-18 — tap for who they are
Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. Last stated 2 months ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. — tap to centre the map on it Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence. — tap to centre the map on it Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence. Last stated a year ago
29 Jun 2025
EH
Elliot Hershberg — holds since 2025-06-29 — tap for who they are
Same subject: A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock. — tap to centre the map on it A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock. Last stated 7 months ago
3 Mar 2026
SB
Sanjay Bakshi — holds since 2026-03-03 — tap for who they are
Same subject: A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved. — tap to centre the map on it A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved. Last stated 3 months ago
30 Jun 2026
GS
Grant Sanderson — holds since 2026-06-30 — tap for who they are
Same subject: A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent. — tap to centre the map on it A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent. Last stated 3 months ago
30 Jun 2026
GS
Grant Sanderson — holds since 2026-06-30 — tap for who they are
Same subject: A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute. — tap to centre the map on it A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute. Last stated 3 weeks ago
22 Sept 2026
TC
Tyler Cowen — holds since 2026-09-22 — tap for who they are
Same subject: AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started. — tap to centre the map on it AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started. Last stated 2 months ago
3 Aug 2026
CP
Chamath Palihapitiya — holds since 2026-08-03 — tap for who they are
Same subject: AI research will be fully automated around 2030 or 2031, and AI will beat humans at essentially any job by about 2033. — tap to centre the map on it AI research will be fully automated around 2030 or 2031, and AI will beat humans at essentially any job by about 2033. Last stated 2 months ago
11 Aug 2026
RG
Ryan Greenblatt — holds since 2026-08-11 — tap for who they are
At the centre
Biological self-organisation is less remarkable than it seems, and almost inevitable given local interactions.
Holds Read this korrent →
Life may be an inevitable, emergent property of any random dynamical system with a Markov blanket.
Holds
Any ergodic system with a Markov blanket will almost surely behave in lifelike ways; nothing suggests a special role for carbon.
Holds
AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work.
Holds
Making a change within a complex system tends to produce unforeseen and unintended consequences.
Holds
Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it.
Holds
Having a biochemical pathway does not mean something will produce an outcome, though any real outcome has a mechanism behind it.
Holds
Unlike physics, biology's complexity and nonlinearity make a brute-force approach to knowledge creation necessary rather than one based on writing down equations.
Holds
Change from already-capable AI is inevitable no matter how the frontier is paced, though it will be uneven and not all at once.
Holds
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Holds
Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility.
Holds
Deep learning has effectively solved the problem of predicting a protein's 3D structure from its sequence.
Holds
A persistently rising dividend yield eventually forces capital appreciation as the market rerates the stock.
Holds
A proof and an explanation are different things, and a theorem can stay an unsolved expository problem long after it is proved.
Holds
A stream of AI-written papers with any error rate at all becomes insufferable, because finding the error costs more than the paper is worth even at ninety-nine percent.
Holds
A ban on self-recursive improvement in AI models would create a big incentive for some other parts of the world to invest a lot more in compute.
Holds
AI is already inside the recursive self-improvement loop — what the labs have shipped in recent weeks shows the cycle has started.
Holds
AI research will be fully automated around 2030 or 2031, and AI will beat humans at essentially any job by about 2033.
Holds