Karl Friston
Neuroscientist at University College London; developer of the free-energy principle and active inference, and of statistical parametric mapping for brain imaging.
From their papers REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics5 korrents Life as we know it4 korrents
Cited by Scott AlexanderSee it on the map
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Their wordsWe end by discussing further implications of the model, such as that psychedelics can bring about the revision of other heavily weighted high-level priors, not directly related to mental health, such as those underlying partisan and/or overly-confident political, religious, and/or philosophical perspectives.
↗REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelicspmc.ncbi.nlm.nih.gov All 10 from this paper
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Their wordsThe resulting synthesis states that psychedelics work to relax high-level priors, sensitising them to liberated bottom-up information flow, which, with the right intention, care provision and context, can help guide and cultivate the revision of entrenched pathological priors.
↗REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelicspmc.ncbi.nlm.nih.gov All 10 from this paper
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Our reading
Psychedelics may be therapeutic precisely because they act on the brain's highest-level beliefs.
Their wordsIn this paper, we propose that psychedelics can be therapeutically effective, precisely because they target the high levels of the brain’s functional hierarchy, primarily affecting the precision weighting of high-level priors or beliefs.
↗REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelicspmc.ncbi.nlm.nih.gov All 10 from this paper
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Their wordsReliable and robust models of natural phenomena, of the sort that science endeavors to discover and finesse, serve us best, as they are less likely to betray us, leaving us open to logical fallacies, dogmatism, absolutism, and an emotional and existential instability.
↗REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelicspmc.ncbi.nlm.nih.gov All 10 from this paper
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Their wordsIt is an ideal of psychedelic therapy that this newly available content be appropriately integrated and assimilated into existing mental models so that more of the inner and outer world can be processed.
↗REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelicspmc.ncbi.nlm.nih.gov All 10 from this paper
- 6 years earlier
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Our reading
Life may be an inevitable, emergent property of any random dynamical system with a Markov blanket.
Their wordsThis paper presents a heuristic proof (and simulations of a primordial soup) suggesting that life—or biological self-organization—is an inevitable and emergent property of any (ergodic) random dynamical system that possesses a Markov blanket.
↗Life as we know itpmc.ncbi.nlm.nih.gov All 4 from this paper
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Their wordsThis paper suggests that biological self-organization is not as remarkable as one might think—and is (almost) inevitable, given local interactions between the states of coupled dynamical systems.
↗Life as we know itpmc.ncbi.nlm.nih.gov All 4 from this paper
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Their wordsPut simply, biological systems move around in their state space but revisit a limited number of states.
↗Life as we know itpmc.ncbi.nlm.nih.gov All 4 from this paper
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Their wordsNothing in this treatment suggests a special role for carbon-based life or, more generally, the necessary conditions for life to emerge. The contribution of this work is to note that if systems are ergodic and possess a Markov blanket, they will—almost surely—show lifelike behaviour.
↗Life as we know itpmc.ncbi.nlm.nih.gov All 4 from this paper