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REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

Robin Carhart-Harris, Karl Friston · 20 Jun 2019

Read the paper on pmc.ncbi.nlm.nih.gov ↗

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Robin Carhart-Harris, Karl Friston did not write this page.

Every claim below was made in this piece, quoted word for word and numbered in the order the piece makes them, so you can read it there rather than take our word for it. The sentence above each quote is our reading of the claim, not their wording. Each quote was checked against a stored copy of the page at build time; where the two differ, the quote is the fact.

  1. Our reading

    Psychedelics can loosen heavily held political, religious and philosophical convictions, not only pathological ones.

    Their wordsWe end by discussing further implications of the model, such as that psychedelics can bring about the revision of other heavily weighted high-level priors, not directly related to mental health, such as those underlying partisan and/or overly-confident political, religious, and/or philosophical perspectives.

  2. Our reading

    With the right intention, care and context, psychedelics can help revise entrenched pathological beliefs.

    Their wordsThe resulting synthesis states that psychedelics work to relax high-level priors, sensitising them to liberated bottom-up information flow, which, with the right intention, care provision and context, can help guide and cultivate the revision of entrenched pathological priors.

  3. Our reading

    Psychedelics may be therapeutic precisely because they act on the brain's highest-level beliefs.

    Their wordsIn this paper, we propose that psychedelics can be therapeutically effective, precisely because they target the high levels of the brain’s functional hierarchy, primarily affecting the precision weighting of high-level priors or beliefs.

  4. Our reading

    Robust scientific models of nature serve us best, because they are less likely to leave us open to dogmatism and instability.

    Their wordsReliable and robust models of natural phenomena, of the sort that science endeavors to discover and finesse, serve us best, as they are less likely to betray us, leaving us open to logical fallacies, dogmatism, absolutism, and an emotional and existential instability.

  5. Our reading

    Psychedelic therapy should integrate the material it releases into a person's existing mental models.

    Their wordsIt is an ideal of psychedelic therapy that this newly available content be appropriately integrated and assimilated into existing mental models so that more of the inner and outer world can be processed.

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