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← The human data an AI model would need to predict trial outcomes can…
17 connected korrents · 16 moments on record from 25 May 2023 to 1 Sept 2026.
Everything filed under design
design
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robotics
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AI alignment
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simplicity Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves. The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves. Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: There is no real impediment to models running their own research loop and improving themselves at a far more rapid rate. — tap to centre the map on it There is no real impediment to models running their own research loop and improving themselves at a far more rapid… Last stated a month ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and… Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans. — tap to centre the map on it Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety… Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often. — tap to centre the map on it We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic… Last stated 3 years ago
25 May 2023
DL
Derek Lowe — holds since 2023-05-25 — tap for who they are
Same subject: Learned approximations of slow simulators change what science is possible, by turning a six-month screening run into something you do over lunch. — tap to centre the map on it Learned approximations of slow simulators change what science is possible, by turning a six-month screening run into… Last stated a month ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Hand-tuning a robot's data set cannot reach very high reliability, because people get tired; the system has to seek out its own missing data. — tap to centre the map on it Hand-tuning a robot's data set cannot reach very high reliability, because people get tired; the system has to… Last stated 4 weeks ago
12 Aug 2026
CF
Chelsea Finn — holds since 2026-08-12 — tap for who they are
Same subject: Scaling up spending on expert human data has not been a major driver of progress in AI research. — tap to centre the map on it Scaling up spending on expert human data has not been a major driver of progress in AI research. Last stated 4 weeks ago
11 Aug 2026
RG
Ryan Greenblatt — holds since 2026-08-11 — tap for who they are
Same subject: AI systems keep trying hard outside training because a model that only exerted itself when it detected training would be useless and would be selected away. — tap to centre the map on it AI systems keep trying hard outside training because a model that only exerted itself when it detected training… Last stated 6 days ago
1 Sept 2026
AC
Ajeya Cotra — holds since 2026-09-01 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. — tap to centre the map on it A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone… Last stated a year ago
23 Mar 2025
RV
Rahul Vohra — holds since 2025-03-23 — tap for who they are
Same subject: A computer meant for anyone has to be understandable without a manual, and it has to be friendly. — tap to centre the map on it A computer meant for anyone has to be understandable without a manual, and it has to be friendly. Last stated 3 weeks ago
14 Aug 2026
SK
Susan Kare — holds since 2026-08-14 — tap for who they are
Same subject: A highly dynamic economy that cheaply mass-produces robots may increase rather than decrease the risk of Malthusian resource dilemmas. — tap to centre the map on it A highly dynamic economy that cheaply mass-produces robots may increase rather than decrease the risk of… Last stated 3 years ago
1 Oct 2023
TC
Tyler Cowen — holds since 2023-10-01 — tap for who they are
Same subject: A humanoid robot is the wrong tool on a factory floor, because a machine specialised in the task beats it. — tap to centre the map on it A humanoid robot is the wrong tool on a factory floor, because a machine specialised in the task beats it. Last stated a year ago
6 Apr 2025
MH
Molson Hart — holds since 2025-04-06 — tap for who they are
Same subject: A physical AI agent has to be safe on day one, because you cannot ship something merely good enough and let users find the edge cases. — tap to centre the map on it A physical AI agent has to be safe on day one, because you cannot ship something merely good enough and let users find… Last stated a month ago
3 Aug 2026
DD
Dmitri Dolgov — holds since 2026-08-03 — tap for who they are
Same subject: After a decade of Swiss minimalism, design is about to swing back to something far more expressive. — tap to centre the map on it After a decade of Swiss minimalism, design is about to swing back to something far more expressive. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely… Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Better design does not mean more design: the most obvious designs are often invisible. — tap to centre the map on it Better design does not mean more design: the most obvious designs are often invisible. Last stated 3 years ago
16 Nov 2023
JZ
Julie Zhuo — holds since 2023-11-16 — tap for who they are
At the centre
The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves.
Holds RT Ruxandra TesloRead this korrent →
There is no real impediment to models running their own research loop and improving themselves at a far more rapid rate.
Holds JD Jeff Dean
Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.
Holds RT Ruxandra Teslo
Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans.
Holds AT Alex Telford
We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often.
Holds DL Derek Lowe
Learned approximations of slow simulators change what science is possible, by turning a six-month screening run into something you do over lunch.
Holds JD Jeff Dean
Hand-tuning a robot's data set cannot reach very high reliability, because people get tired; the system has to seek out its own missing data.
Holds CF Chelsea Finn
Scaling up spending on expert human data has not been a major driver of progress in AI research.
Holds RG Ryan Greenblatt
AI systems keep trying hard outside training because a model that only exerted itself when it detected training would be useless and would be selected away.
Holds AC Ajeya Cotra
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds JZ Julie Zhuo
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Holds RV Rahul Vohra
A computer meant for anyone has to be understandable without a manual, and it has to be friendly.
Holds SK Susan Kare
A highly dynamic economy that cheaply mass-produces robots may increase rather than decrease the risk of Malthusian resource dilemmas.
Holds TC Tyler Cowen
A humanoid robot is the wrong tool on a factory floor, because a machine specialised in the task beats it.
Holds MH Molson Hart
A physical AI agent has to be safe on day one, because you cannot ship something merely good enough and let users find the edge cases.
Holds DD Dmitri Dolgov
After a decade of Swiss minimalism, design is about to swing back to something far more expressive.
Holds DF Dylan Field
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Better design does not mean more design: the most obvious designs are often invisible.
Holds JZ Julie Zhuo