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← No amount of animal testing can guarantee a drug is safe in humans, so…
17 connected korrents · 16 moments from 29 Sept 2018 to 4 Oct 2026.
Everything filed under design
design
Everything filed under AI and science
AI and science
Everything filed under taste
taste
Everything filed under simplicity
simplicity
Everything filed under documentation
documentation
Everything filed under self-driving cars
self-driving cars
Everything filed under behavioural science
behavioural science Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: No amount of animal testing can guarantee a drug is safe in humans, so human volunteers must carry some irreducible risk for medicine to advance. No amount of animal testing can guarantee a drug is safe in humans, so human volunteers must carry some irreducible risk for medicine to advance. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: A clinical trial is not only a test of a drug: early trials are experiments whose real product is the human biology data everything downstream is built on. — tap to centre the map on it A clinical trial is not only a test of a drug: early trials are experiments whose real product is the human biology data everything downstream is built on. Last stated 8 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 3 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans. — tap to centre the map on it Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves. — tap to centre the map on it The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves. Last stated 8 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. — tap to centre the map on it Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. Last stated 6 years ago
1 May 2020
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
Same subject: Every mile of public-road testing adds risk, so each one has to earn its keep. — tap to centre the map on it Every mile of public-road testing adds risk, so each one has to earn its keep. Last stated 6 years ago
25 Nov 2020
PK
Philip Koopman — holds since 2020-11-25 — tap for who they are
Same subject: Most people are fundamentally good, which makes the risk of trusting them worth taking. — tap to centre the map on it Most people are fundamentally good, which makes the risk of trusting them worth taking. Last stated 3 years ago
9 Mar 2024
MM
Mark Manson — holds since 2024-03-09 — tap for who they are
Same subject: No AI system today reduces either of the two risks that sink most drugs in the clinic: picking the wrong target, and human toxicity. — tap to centre the map on it No AI system today reduces either of the two risks that sink most drugs in the clinic: picking the wrong target, and human toxicity. Last stated 3 years ago
25 May 2023
DL
Derek Lowe — holds since 2023-05-25 — tap for who they are
Same subject: A $1,299, 100-gram pair of slip-on glasses seems far more enticing than a $3,699, 700-gram headset strapped to the face. — tap to centre the map on it A $1,299, 100-gram pair of slip-on glasses seems far more enticing than a $3,699, 700-gram headset strapped to the face. Last stated 4 weeks ago
24 Sept 2026
MS
M.G. Siegler — holds since 2026-09-24 — tap for who they are
Same subject: A baby-step version of eval-driven design is to sketch out 10 to 20 hero flows and run the feature or interaction through them to see where it falls apart. — tap to centre the map on it A baby-step version of eval-driven design is to sketch out 10 to 20 hero flows and run the feature or interaction through them to see where it falls apart. Last stated a month ago
9 Sept 2026
EB
Ed Bayes — holds since 2026-09-09 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A browser works better as a single window than as multiple separate windows. — tap to centre the map on it A browser works better as a single window than as multiple separate windows. Last stated a month ago
15 Sept 2026
CC
Chris Coyier — holds since 2026-09-15 — tap for who they are
Same subject: A business is more likely to fail from taking on too much complexity than from lacking resources. — tap to centre the map on it A business is more likely to fail from taking on too much complexity than from lacking resources. Last stated 8 years ago
29 Sept 2018
TG
Tren Griffin — holds since 2018-09-29 — tap for who they are
Same subject: A business succeeds through a small number of highly effective distribution channels, not many mediocre ones. — tap to centre the map on it A business succeeds through a small number of highly effective distribution channels, not many mediocre ones. Last stated 3 years ago
17 Feb 2024
AW
Adam Wiggins — holds since 2024-02-17 — tap for who they are
Same subject: A big part of taste is delivering high levels of craft in an accessible way so that as many people as possible can experience it. — tap to centre the map on it A big part of taste is delivering high levels of craft in an accessible way so that as many people as possible can experience it. Last stated 6 months ago
21 Apr 2026
BJ
Brandon Jacoby — holds since 2026-04-21 — tap for who they are
Same subject: A company name can have different appeal to corporate buyers versus their customers. — tap to centre the map on it A company name can have different appeal to corporate buyers versus their customers. Last stated 3 weeks ago
4 Oct 2026
PG
Paul Graham — holds since 2026-10-04 — tap for who they are
Same subject: A first draft should not be graded good or bad; it is only the material that taste then gets to act on. — tap to centre the map on it A first draft should not be graded good or bad; it is only the material that taste then gets to act on. Last stated 3 months ago
6 Aug 2026
GS
George Saunders — holds since 2026-08-06 — tap for who they are
At the centre
No amount of animal testing can guarantee a drug is safe in humans, so human volunteers must carry some irreducible risk for medicine to advance.
Holds Read this korrent →
A clinical trial is not only a test of a drug: early trials are experiments whose real product is the human biology data everything downstream is built on.
Holds
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds
Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans.
Holds
The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves.
Holds
Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer.
Holds
Every mile of public-road testing adds risk, so each one has to earn its keep.
Holds
Most people are fundamentally good, which makes the risk of trusting them worth taking.
Holds
No AI system today reduces either of the two risks that sink most drugs in the clinic: picking the wrong target, and human toxicity.
Holds
A $1,299, 100-gram pair of slip-on glasses seems far more enticing than a $3,699, 700-gram headset strapped to the face.
Holds
A baby-step version of eval-driven design is to sketch out 10 to 20 hero flows and run the feature or interaction through them to see where it falls apart.
Holds
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds
A browser works better as a single window than as multiple separate windows.
Holds
A business is more likely to fail from taking on too much complexity than from lacking resources.
Holds
A business succeeds through a small number of highly effective distribution channels, not many mediocre ones.
Holds
A big part of taste is delivering high levels of craft in an accessible way so that as many people as possible can experience it.
Holds
A company name can have different appeal to corporate buyers versus their customers.
Holds
A first draft should not be graded good or bad; it is only the material that taste then gets to act on.
Holds