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← No amount of animal testing can guarantee a drug is safe in humans, so…
16 connected korrents · 14 moments on record from 1 May 2020 to 14 Aug 2026.
Everything filed under design
design
Everything filed under documentation
documentation
Everything filed under simplicity
simplicity Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: No amount of animal testing can guarantee a drug is safe in humans, so human volunteers must carry some irreducible risk for medicine to advance. No amount of animal testing can guarantee a drug is safe in humans, so human volunteers must carry some irreducible risk for medicine to advance. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: A clinical trial is not only a test of a drug: early trials are experiments whose real product is the human biology data everything downstream is built on. — tap to centre the map on it A clinical trial is not only a test of a drug: early trials are experiments whose real product is the human biology data everything downstream is built on. Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans. — tap to centre the map on it Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves. — tap to centre the map on it The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves. Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. — tap to centre the map on it Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. Last stated 6 years ago
1 May 2020
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
Same subject: Every mile of public-road testing adds risk, so each one has to earn its keep. — tap to centre the map on it Every mile of public-road testing adds risk, so each one has to earn its keep. Last stated 6 years ago
25 Nov 2020
PK
Philip Koopman — holds since 2020-11-25 — tap for who they are
Same subject: No AI system today reduces either of the two risks that sink most drugs in the clinic: picking the wrong target, and human toxicity. — tap to centre the map on it No AI system today reduces either of the two risks that sink most drugs in the clinic: picking the wrong target, and human toxicity. Last stated 3 years ago
25 May 2023
DL
Derek Lowe — holds since 2023-05-25 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. — tap to centre the map on it A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. Last stated a year ago
23 Mar 2025
RV
Rahul Vohra — holds since 2025-03-23 — tap for who they are
Same subject: A computer meant for anyone has to be understandable without a manual, and it has to be friendly. — tap to centre the map on it A computer meant for anyone has to be understandable without a manual, and it has to be friendly. Last stated 4 weeks ago
14 Aug 2026
SK
Susan Kare — holds since 2026-08-14 — tap for who they are
Same subject: A design proposal should describe the feature as though it already existed — once as a tutorial and once as reference documentation. — tap to centre the map on it A design proposal should describe the feature as though it already existed — once as a tutorial and once as reference documentation. Last stated 4 months ago
20 May 2026
AR
Alice Ryhl — holds since 2026-05-20 — tap for who they are
Same subject: Do not run a personal agent on a cheap or local model: weak models are gullible and easy to prompt-inject. — tap to centre the map on it Do not run a personal agent on a cheap or local model: weak models are gullible and easy to prompt-inject. Last stated 7 months ago
12 Feb 2026
PS
Peter Steinberger — holds since 2026-02-12 — tap for who they are
Same subject: Examples in documentation should be compiled and run as tests, so that changing the code breaks the docs instead of quietly outdating them. — tap to centre the map on it Examples in documentation should be compiled and run as tests, so that changing the code breaks the docs instead of quietly outdating them. Last stated 4 months ago
20 May 2026
AR
Alice Ryhl — holds since 2026-05-20 — tap for who they are
Same subject: After a decade of Swiss minimalism, design is about to swing back to something far more expressive. — tap to centre the map on it After a decade of Swiss minimalism, design is about to swing back to something far more expressive. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Better design does not mean more design: the most obvious designs are often invisible. — tap to centre the map on it Better design does not mean more design: the most obvious designs are often invisible. Last stated 3 years ago
16 Nov 2023
JZ
Julie Zhuo — holds since 2023-11-16 — tap for who they are
At the centre
No amount of animal testing can guarantee a drug is safe in humans, so human volunteers must carry some irreducible risk for medicine to advance.
Holds AT Alex TelfordRead this korrent →
A clinical trial is not only a test of a drug: early trials are experiments whose real product is the human biology data everything downstream is built on.
Holds RT Ruxandra Teslo
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds AT Alex TelfordRT Ruxandra Teslo
Deep learning is not yet ready for the task that would actually add value in drug development: predicting safety and efficacy in humans.
Holds AT Alex Telford
The human data an AI model would need to predict trial outcomes can only come from trials in people, so the loop runs no faster than the trials themselves.
Holds RT Ruxandra Teslo
Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer.
Holds DL Derek Lowe
Every mile of public-road testing adds risk, so each one has to earn its keep.
Holds PK Philip Koopman
No AI system today reduces either of the two risks that sink most drugs in the clinic: picking the wrong target, and human toxicity.
Holds DL Derek Lowe
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds JZ Julie Zhuo
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Holds RV Rahul Vohra
A computer meant for anyone has to be understandable without a manual, and it has to be friendly.
Holds SK Susan Kare
A design proposal should describe the feature as though it already existed — once as a tutorial and once as reference documentation.
Holds AR Alice Ryhl
Do not run a personal agent on a cheap or local model: weak models are gullible and easy to prompt-inject.
Holds
Examples in documentation should be compiled and run as tests, so that changing the code breaks the docs instead of quietly outdating them.
Holds AR Alice Ryhl
After a decade of Swiss minimalism, design is about to swing back to something far more expressive.
Holds DF Dylan Field
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Better design does not mean more design: the most obvious designs are often invisible.
Holds JZ Julie Zhuo