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← A supplement or drug should be judged on well-defined benefits for…
17 connected korrents · 17 moments on record from 8 Mar 2012 to 1 Sept 2026.
Everything filed under design
design
Everything filed under AI alignment
AI alignment
Everything filed under health and fitness
health and fitness
Everything filed under simplicity
simplicity Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: A supplement or drug should be judged on well-defined benefits for well-defined problems in well-defined populations, never on a vague promise of slowing ageing. A supplement or drug should be judged on well-defined benefits for well-defined problems in well-defined populations, never on a vague promise of slowing ageing. Last stated 2 months ago
4 Jul 2026
PA
Peter Attia — holds since 2026-07-04 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Aging is neglected not for technical reasons but because it is not yet socially classified as a disease. — tap to centre the map on it Aging is neglected not for technical reasons but because it is not yet socially classified as a disease. Last stated 7 months ago
29 Jan 2026
LD
Laura Deming — holds since 2026-01-29 — tap for who they are
Same subject: Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. — tap to centre the map on it Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. Last stated 14 years ago
8 Mar 2012
DL
Derek Lowe — holds since 2012-03-08 — tap for who they are
Same subject: Metformin is not a general-purpose anti-cancer or anti-ageing drug, and healthy people should not take it as one. — tap to centre the map on it Metformin is not a general-purpose anti-cancer or anti-ageing drug, and healthy people should not take it as one. Last stated 2 months ago
4 Jul 2026
PA
Peter Attia — holds since 2026-07-04 — tap for who they are
Same subject: The evidence on nutrients supports exactly one instruction, do not be deficient, and nothing is known about pushing a level above the normal range. — tap to centre the map on it The evidence on nutrients supports exactly one instruction, do not be deficient, and nothing is known about pushing a level above the normal range. Last stated 2 months ago
20 Jul 2026
TW
Tommy Wood — holds since 2026-07-20 — tap for who they are
Same subject: Exercise is the most powerful broad-based longevity intervention available today, and a drug that blunts its adaptations is not worth taking for longevity. — tap to centre the map on it Exercise is the most powerful broad-based longevity intervention available today, and a drug that blunts its adaptations is not worth taking for longevity. Last stated 2 months ago
4 Jul 2026
PA
Peter Attia — holds since 2026-07-04 — tap for who they are
Same subject: AI research is on a good trajectory overall — good for science and good for society — and existential concerns will only become relevant in the distant future. — tap to centre the map on it AI research is on a good trajectory overall — good for science and good for society — and existential concerns will only become relevant in the distant future. Last stated 3 years ago
12 Aug 2023
YB
Yoshua Bengio — holds since 2023-08-12 — tap for who they are
YB
Yoshua Bengio — no longer holds since 2023-08-12 — tap for who they are
Same subject: Health optimisation has overshot: minimising a measured risk is not worth it if the cost is not having lived. — tap to centre the map on it Health optimisation has overshot: minimising a measured risk is not worth it if the cost is not having lived. Last stated 2 weeks ago
26 Aug 2026
DH
David Heinemeier Hansson — holds since 2026-08-26 — tap for who they are
Same subject: A human being is not an AGI: we lack a huge amount of knowledge and rely on continual learning instead, so continual learning is what superintelligence should mean. — tap to centre the map on it A human being is not an AGI: we lack a huge amount of knowledge and rely on continual learning instead, so continual learning is what superintelligence should mean. Last stated 9 months ago
25 Nov 2025
IS
Ilya Sutskever — holds since 2025-11-25 — tap for who they are
Same subject: A saboteur among our AI investigators would be hard to spot, because these models are sloppy and spiky enough that a suspicious error just looks like ordinary incompetence. — tap to centre the map on it A saboteur among our AI investigators would be hard to spot, because these models are sloppy and spiky enough that a suspicious error just looks like ordinary incompetence. Last stated 6 days ago
1 Sept 2026
AC
Ajeya Cotra — holds since 2026-09-01 — tap for who they are
Same subject: A superintelligence needs no consciousness, emotions or malice to be dangerous; a goal system slightly misaligned with ours is enough. — tap to centre the map on it A superintelligence needs no consciousness, emotions or malice to be dangerous; a goal system slightly misaligned with ours is enough. Last stated 9 years ago
24 Oct 2017
ÉT
Émile P. Torres — holds since 2017-10-24 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. — tap to centre the map on it A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. Last stated a year ago
23 Mar 2025
RV
Rahul Vohra — holds since 2025-03-23 — tap for who they are
Same subject: A computer meant for anyone has to be understandable without a manual, and it has to be friendly. — tap to centre the map on it A computer meant for anyone has to be understandable without a manual, and it has to be friendly. Last stated 3 weeks ago
14 Aug 2026
SK
Susan Kare — holds since 2026-08-14 — tap for who they are
Same subject: After a decade of Swiss minimalism, design is about to swing back to something far more expressive. — tap to centre the map on it After a decade of Swiss minimalism, design is about to swing back to something far more expressive. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Better design does not mean more design: the most obvious designs are often invisible. — tap to centre the map on it Better design does not mean more design: the most obvious designs are often invisible. Last stated 3 years ago
16 Nov 2023
JZ
Julie Zhuo — holds since 2023-11-16 — tap for who they are
At the centre
A supplement or drug should be judged on well-defined benefits for well-defined problems in well-defined populations, never on a vague promise of slowing ageing.
Holds PA Peter AttiaRead this korrent →
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds AT Alex TelfordRT Ruxandra Teslo
Aging is neglected not for technical reasons but because it is not yet socially classified as a disease.
Holds LD Laura Deming
Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time.
Holds DL Derek Lowe
Metformin is not a general-purpose anti-cancer or anti-ageing drug, and healthy people should not take it as one.
Holds PA Peter Attia
The evidence on nutrients supports exactly one instruction, do not be deficient, and nothing is known about pushing a level above the normal range.
Holds TW Tommy Wood
Exercise is the most powerful broad-based longevity intervention available today, and a drug that blunts its adaptations is not worth taking for longevity.
Holds PA Peter Attia
AI research is on a good trajectory overall — good for science and good for society — and existential concerns will only become relevant in the distant future.
No longer holds
Health optimisation has overshot: minimising a measured risk is not worth it if the cost is not having lived.
Holds
A human being is not an AGI: we lack a huge amount of knowledge and rely on continual learning instead, so continual learning is what superintelligence should mean.
Holds IS Ilya Sutskever
A saboteur among our AI investigators would be hard to spot, because these models are sloppy and spiky enough that a suspicious error just looks like ordinary incompetence.
Holds AC Ajeya Cotra
A superintelligence needs no consciousness, emotions or malice to be dangerous; a goal system slightly misaligned with ours is enough.
Holds ÉT Émile P. Torres
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds JZ Julie Zhuo
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Holds RV Rahul Vohra
A computer meant for anyone has to be understandable without a manual, and it has to be friendly.
Holds SK Susan Kare
After a decade of Swiss minimalism, design is about to swing back to something far more expressive.
Holds DF Dylan Field
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Better design does not mean more design: the most obvious designs are often invisible.
Holds JZ Julie Zhuo