korrents

Laura Deming

@laura-deming · 15 positions · 0 changes of mind

Co-founder and CEO of Until, a reversible-cryopreservation company, and previously the founder of the Longevity Fund.

Laura Deming did not write this page.

We collected these quotes from things they published elsewhere, and every quote links to where it was said. They have no account here and have not endorsed this site. Quotes are word for word; the short line under each one is our own restatement, not their wording. Their own site. Is this you? Claim it or ask us to remove it. Or tell us what is wrong here.

  1. Our reading

    Aging is neglected not for technical reasons but because it is not yet socially classified as a disease.

    Their wordsI think longevity and aging kind of occupy this weird realm where because they're not like explicitly diseases in a way that's fully socially recognized yet they're not seen as valid to work on but like that's not really for I think technical reasons on some level it's more for like classification reasons
    spoken · machine transcript hear it at 2:42 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 1st of 15 in this recording

    Interesting

  3. Our reading

    The areas worth working on are the ones with a social blind spot around them.

    Their wordsI think longevity is interesting because it feels like an area where there's a social blind spot around something and I find those very interesting.
    spoken · machine transcript hear it at 3:09 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 2nd of 15 in this recording

    Interesting

  5. Our reading

    Medicine needs an ambulance of the future: a way to pause a dying patient's biological time until the cure for their disease arrives.

    Their wordsBut right now like there's no way to press pause on their biological time. So like what if you had an ambulance of the future, right? Like what if you could take someone who is on their deathbed and um you know find some way to you know just sort of hibernate them basically until um the sort of critical cure for their disease comes online.
    spoken · machine transcript hear it at 8:38 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 3rd of 15 in this recording

    Interesting

  7. Our reading

    What will limit medical hibernation is not the technology but the social cost -- you cannot take the people around you with you.

    Their wordsbut I think that the thing that a lot of people will face is just like this question of like is it worth you know traveling so far to give up my current social context and that will put a limit on like how much people want to use this for
    spoken · machine transcript hear it at 11:43 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 4th of 15 in this recording

    Interesting

  9. Our reading

    Cryopreservation is tractable because ice formation is a probabilistic process you can steer, not a threshold that flips.

    Their wordsbut ice sort of forms through a process of random nucleation and then extension. And this is cool because you can uh modulate the like sort of nucleation the rate of nucleation and extension to then modulate the probability of ice formation.
    spoken · machine transcript hear it at 13:08 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 5th of 15 in this recording

    Interesting

  11. Our reading

    We already reversibly cryopreserve whole human bodies, at the few-hundred-cell stage, so the open question is scale and not possibility.

    Their wordsAnd so that's the last thing which was very surprising to me which is that like we already reversibly cry preserve tissue including human tissue including whole body human tissue at that very very small like you know in a couple hundred cells stage
    spoken · machine transcript hear it at 14:44 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 6th of 15 in this recording

    Interesting

  13. Our reading

    In cryopreservation you can buy down biological difficulty with better engineering, which is not true of most problems in biology.

    Their wordsyou can make your life easier on the biology front by building better engineering tooling and the fact that that's possible is a huge deal. Like that is that is not true for most problems in biology and it gives you a lot of leverage on the problem.
    spoken · machine transcript hear it at 16:25 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 7th of 15 in this recording

    Interesting

  15. Our reading

    Temperature is a rare conceptual lever that lets you use physics to reason usefully about a biological problem.

    Their wordsBasically what that gives you is like you can apply a lot of theoretical sort of um a lot of theoretical toolkit used in physics to model parts of this question in ways that are actually useful. And it is just not true that you can use like equations from physics to think usefully about almost any other problem in biology.
    spoken · machine transcript hear it at 17:22 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 8th of 15 in this recording

    physics

    Interesting

  17. Our reading

    The brain is the one real unknown standing between organ cryopreservation and reversible whole-body preservation.

    Their wordsthe big unknown to get to whole body reversible is the brain. Um it's unclear like like the brain can withstand a lot of change and does withstand a lot of different types of damage or or change with age for example.
    spoken · machine transcript hear it at 21:20 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 9th of 15 in this recording

    Interesting

  19. Our reading

    Transplant patients regularly lose organs that are already on their way to them, purely because of timing.

    Their wordsbasically transplant patients today surprisingly frequently miss organs that are on route to them because there's a timing problem. Um, so like you know, organs expire um very quickly after they become available from a donor.
    spoken · machine transcript hear it at 22:10 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 10th of 15 in this recording

    Interesting

  21. Our reading

    Organs are among the most precious resources there are, and the system still moves them by putting a surgeon on a chartered jet at the last minute.

    Their wordsAnd it's crazy because like they're the they're like one of the most precious resources we know of. And yet like people regularly charter private jets, you know, like like you're putting a surgeon on a private jet to go pick up an organ, get it back to the patient in time.
    spoken · machine transcript hear it at 22:24 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 11th of 15 in this recording

    Interesting

  23. Our reading

    Whole-body preservation cannot be discussed rationally: people either love it uncritically or fear that taking it seriously will taint them.

    Their wordspeople either like love it and they love it so much that they won't question it or it's like they're worried that thinking about that associating with it is a little bit too science fiction for kind of where it might be optimal for them to be focused.
    spoken · machine transcript hear it at 26:03 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 12th of 15 in this recording

    Interesting

  25. Our reading

    The cruelty of the transplant system is what it does to the patient: waiting for a life-changing surgery with no idea when it will be scheduled.

    Their wordsI think the thing that feels the most compelling for me is just like the experience of the transplant patient. It's really I think constricting. It's like you're waiting for a life-changing surgery and you have no idea when it will even be scheduled
    spoken · machine transcript hear it at 27:37 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 13th of 15 in this recording

    Interesting

  27. Our reading

    Organ matching happens at literally the last minute, so nobody has the time to find the best match.

    Their wordsAnd then I also think um you know right now for matching it's like everything's done at literally the last minute. It's like someone dies, an organ comes available and like you're just kind of calling around trying to find like what patient is available to get this organ and you don't have that much time to make the optimal match, right?
    spoken · machine transcript hear it at 28:09 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 14th of 15 in this recording

    Interesting

  29. Our reading

    Biology is taught as flat triangles and arrows in a textbook, a depiction of the molecular world that makes no conceptual sense.

    Their wordsand I think most people experience it as like flat triangles and squares in a biology textbook where it's like you know there's an arrow between like this triangle and this triangle is just like doesn't make any conceptual sense and is like confusing and annoying
    spoken · machine transcript hear it at 29:42 · all korrents from this recording

    ↗How Until is Engineering Away Time in Organ Transplants | Laura Demingyoutube.com 15th of 15 in this recording

    Interesting