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Alex Telford

What Alex Telford thinks about innovation

@alex-telford · 12 positions · On ppll ↗

Writer on biotechnology and the economics of drug development, with a background working in and around the pharmaceutical industry. He writes long, sourced essays at atelfo.github.io on why drugs are hard to discover, what regulation does to that, and where the industry is going.

Alex Telford did not write this page.

We collected these quotes from things they published elsewhere, and every quote links to where it was said. They have no account here and have not endorsed this site. Quotes are word for word; the short line under each one is our own restatement, not their wording. Their own site. Is this you? Claim it or ask us to remove it. Or tell us what is wrong here.

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4 dated positions, 2023 to 2024, in their own words. Our reading of what Alex Telford has said — not written or endorsed by them.

4 positions so far — this page is not yet offered to search engines.

  1. Our readingThe West has not yet internalised that China is a source of genuinely new drugs, not just a maker of ingredients and copies.

    China

    Their wordsI don’t think many in the West have yet fully internalized a mental model of China as a source of genuine innovation.

    ↗Will all our drugs come from China?atelfo.github.io 1st of 2 in this piece

  2. 12 months earlier

  3. Our readingA drug discovery scientist starting today will probably retire without ever having worked on a drug that reached the market.

    Their wordsSuch prolificacy is unlikely to be repeated any time soon; if current trends hold, a drug discovery scientist starting their career today is likely to retire without ever having worked on a single drug that makes it to market.

    ↗The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about itatelfo.github.io 1st of 9 in this piece

  5. Our readingPharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market.

    Their wordsThe cost to discover and develop a drug today is orders of magnitude higher than in the 1950s. Despite this, the probability that a drug entering clinical trials will eventually reach the market has hardly improved in the intervening years.

    ↗The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about itatelfo.github.io 2nd of 9 in this piece

  7. Our readingThe pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once.

    Their wordsIn reality, the productivity crisis in the pharmaceutical industry is the culmination of decades of just about every aspect of drug discovery and development getting gradually harder and more expensive.

    ↗The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about itatelfo.github.io 3rd of 9 in this piece