The pharmaceutical productivity crisis has no single villain: nearly every part of discovery and development got gradually harder and more expensive at once.

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• Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. ATAlex Telford23 Dec 2023similar wording
• Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. DLDerek Lowe8 Mar 2012similar wording
• Drug research is heading, at speed, for a world in which fewer and fewer useful medicines are discovered while more and more people want them. DLDerek Lowe8 Mar 2012similar wording
• A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck. ATAlex Telford17 Sept 2024similar wording

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