Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time.

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• The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. ATAlex Telford23 Dec 2023
• Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. ATAlex Telford23 Dec 2023
• A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. DLDerek Lowe13 May 2024
• Drug discovery has become less efficient over time despite continued technological progress. EHElliot Hershberg18 Jan 2026
• The number of diseases with a known molecular explanation has grown far faster than the number of new drugs developed to treat them. EHElliot Hershberg16 Feb 2025

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