Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time.

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• The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. ATAlex Telford23 Dec 2023similar wording
• Pharmaceutical R&D productivity has fallen for decades: far more money spent per drug, with no matching improvement in the odds a candidate reaches the market. ATAlex Telford23 Dec 2023similar wording
• A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. DLDerek Lowe13 May 2024similar wording
• The West has not yet internalised that China is a source of genuinely new drugs, not just a maker of ingredients and copies. ATAlex Telford20 Dec 2024similar wording
• Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. RTRuxandra Teslo28 Feb 2026similar wording

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