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The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.

Drawn from what Ruxandra Teslo and Alex Telford said

design
What this subject means

design How things should be made and judged: what makes a design good, who should do the designing, and what an interface is for.

Bottlenecks

What they actually said

  1. Ruxandra Teslo Geneticist by training and writer on science That is mostly in the realm of chemistry and is intrinsically far more tractable and predictable; given a validated target, good teams usually reach a decent molecule. Intelligence is not the main bottleneckwritingruxandrabio.com · 21 Jul 2026All 6 korrents from this piece
    That is mostly in the realm of chemistry and is intrinsically far more tractable and predictable; given a validated target, good teams usually reach a decent molecule.
  2. Alex Telford Writer on biotechnology and the economics of drug development The most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make. The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about itatelfo.github.io · 23 Dec 2023All 9 korrents from this piece
    The most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make.

Added to korrents 7 Sept 2026 · How quotes work · Something wrong? Tell us

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012 Dec 2023 Oct 2026

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