What Alex Telford thinks about design

@alex-telford · 12 positions · On ppll ↗

Writer on biotechnology and the economics of drug development, with a background working in and around the pharmaceutical industry. He writes long, sourced essays at atelfo.github.io on why drugs are hard to discover, what regulation does to that, and where the industry is going.

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1 dated position, 2023, in their own words. Our reading of what Alex Telford has said — not written or endorsed by them.

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1. 23 Dec 2023

   Our readingThe hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.

   Their wordsThe most significant factor preventing us from taking better molecules into clinical trials is not our ability to design arbitrary molecules, but our (lack of) understanding of underlying disease biology. In other words, we often know how to make something, but not what to make.

   ↗The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about itatelfo.github.io 7th of 9 in this piece