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Does energy imbalance (calories in > out) cause obesity?

Stephan Guyenet · 1 Feb 2021 · stephanguyenet.com

6 korrents from this piece

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  1. No matter what your model of obesity is, in order to explain the development of an obese body, energy imbalance has to be a link in the model’s causal chain.
  2. In people living their normal lives, circulating insulin level, and the insulin response to carbohydrate, don’t reliably predict who will gain weight and who won’t.
  3. This is a phenomenon I call the “starvation response”, and it happens because body fat mass is biologically regulated.
  4. This suggests that overfeeding had caused their body fat regulatory system to durably accept a higher “setpoint”.
  5. However, whichever side of the energy balance equation is giving orders, the brain appears to be the commander-in-chief of the equation as a whole.
  6. This tells us that common obesity is not the result of a reduced metabolic rate– a common but erroneous belief.