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← Raising HDL cholesterol is not a treatment target, because every drug…
13 connected korrents · 12 moments on record from 12 Feb 2010 to 14 Aug 2026.
Everything filed under design
design
Everything filed under taste
taste
Everything filed under simplicity
simplicity Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Raising HDL cholesterol is not a treatment target, because every drug that raised it failed to reduce cardiovascular events. Raising HDL cholesterol is not a treatment target, because every drug that raised it failed to reduce cardiovascular events. Last stated 2 months ago
27 Jun 2026
PA
Peter Attia — holds since 2026-06-27 — tap for who they are
Same subject: The phrase "good cholesterol" should be retired: a high HDL-C number is not a free pass on cardiovascular risk. — tap to centre the map on it The phrase "good cholesterol" should be retired: a high HDL-C number is not a free pass on cardiovascular risk. Last stated 2 months ago
27 Jun 2026
PA
Peter Attia — holds since 2026-06-27 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often. — tap to centre the map on it We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often. Last stated 3 years ago
25 May 2023
DL
Derek Lowe — holds since 2023-05-25 — tap for who they are
Same subject: Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. — tap to centre the map on it Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. Last stated 2 months ago
21 Jul 2026
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. — tap to centre the map on it A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem. Last stated a year ago
23 Mar 2025
RV
Rahul Vohra — holds since 2025-03-23 — tap for who they are
Same subject: A computer meant for anyone has to be understandable without a manual, and it has to be friendly. — tap to centre the map on it A computer meant for anyone has to be understandable without a manual, and it has to be friendly. Last stated 3 weeks ago
14 Aug 2026
SK
Susan Kare — holds since 2026-08-14 — tap for who they are
Same subject: After a decade of Swiss minimalism, design is about to swing back to something far more expressive. — tap to centre the map on it After a decade of Swiss minimalism, design is about to swing back to something far more expressive. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Better design does not mean more design: the most obvious designs are often invisible. — tap to centre the map on it Better design does not mean more design: the most obvious designs are often invisible. Last stated 3 years ago
16 Nov 2023
JZ
Julie Zhuo — holds since 2023-11-16 — tap for who they are
Same subject: A first draft should not be graded good or bad; it is only the material that taste then gets to act on. — tap to centre the map on it A first draft should not be graded good or bad; it is only the material that taste then gets to act on. Last stated a month ago
6 Aug 2026
GS
George Saunders — holds since 2026-08-06 — tap for who they are
Same subject: A lot of people can match a framework for taste; almost nobody can create one, and creating one is the rare skill. — tap to centre the map on it A lot of people can match a framework for taste; almost nobody can create one, and creating one is the rare skill. Last stated 11 months ago
16 Oct 2025
DF
Dylan Field — holds since 2025-10-16 — tap for who they are
Same subject: A product needs a soul, and for that it needs one person of great taste who is its living, breathing aspect and gets furious about every small detail. — tap to centre the map on it A product needs a soul, and for that it needs one person of great taste who is its living, breathing aspect and gets furious about every small detail. Last stated 17 years ago
12 Feb 2010
KS
Karri Saarinen — holds since 2010-02-12 — tap for who they are
At the centre
Raising HDL cholesterol is not a treatment target, because every drug that raised it failed to reduce cardiovascular events.
Holds PA Peter AttiaRead this korrent →
The phrase "good cholesterol" should be retired: a high HDL-C number is not a free pass on cardiovascular risk.
Holds PA Peter Attia
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds AT Alex TelfordRT Ruxandra Teslo
We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often.
Holds DL Derek Lowe
Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be.
Holds RT Ruxandra Teslo
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds JZ Julie Zhuo
A company deserves everyone in it, the chief executive included, to spend as much time as possible in their zone of genius — which is an org design problem.
Holds RV Rahul Vohra
A computer meant for anyone has to be understandable without a manual, and it has to be friendly.
Holds SK Susan Kare
After a decade of Swiss minimalism, design is about to swing back to something far more expressive.
Holds DF Dylan Field
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Better design does not mean more design: the most obvious designs are often invisible.
Holds JZ Julie Zhuo
A first draft should not be graded good or bad; it is only the material that taste then gets to act on.
Holds GS George Saunders
A lot of people can match a framework for taste; almost nobody can create one, and creating one is the rare skill.
Holds DF Dylan Field
A product needs a soul, and for that it needs one person of great taste who is its living, breathing aspect and gets furious about every small detail.
Holds KS Karri Saarinen