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← Raising HDL cholesterol is not a treatment target, because every drug…

14 connected korrents · 12 moments from 19 Aug 2004 to 18 Sept 2026.

Everything filed under health and fitness health and fitness Everything filed under Polyvagal theory Polyvagal theory Everything filed under design design Everything filed under surgical outcomes surgical outcomes Everything filed under AI and science AI and science Everything filed under dementia dementia Same subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subjectSame subject Read this korrent: Raising HDL cholesterol is not a treatment target, because every drug that raised it failed to reduce cardiovascular events. Raising HDL cholesterol is not a treatmenttarget, because every drug that raised itfailed to reduce cardiovascular events. Last stated 4 months ago 27 Jun 2026 PA Peter Attia — holds since 2026-06-27 — tap for who they are Same subject: The phrase "good cholesterol" should be retired: a high HDL-C number is not a free pass on cardiovascular risk. — tap to centre the map on it The phrase "good cholesterol" shouldbe retired: a high HDL-C number isnot a free pass on cardiovascularrisk. Last stated 4 months ago 27 Jun 2026 PA Peter Attia — holds since 2026-06-27 — tap for who they are Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery isknowing what to make - which targetis worth drugging - not designingthe molecule. Last stated 3 months ago 21 Jul 2026 AT Alex Telford — holds since 2023-12-23 — tap for who they are RT Ruxandra Teslo — holds since 2026-07-21 — tap for who they are Same subject: Non-risk-adjusted mortality data cannot support patient choice and only signal that a fuller review is required. — tap to centre the map on it Non-risk-adjusted mortality datacannot support patient choice andonly signal that a fuller review isrequired. Last stated 22 years ago 19 Aug 2004 DS David Spiegelhalter — holds since 2004-08-19 — tap for who they are Same subject: We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often. — tap to centre the map on it We have neither the data nor theinsight to use machine learning topick drug targets that succeed inthe clinic more often. Last stated 3 years ago 25 May 2023 DL Derek Lowe — holds since 2023-05-25 — tap for who they are Same subject: Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. — tap to centre the map on it Drug companies pile onto the samefew already-validated targets, sofar less of biology gets exploredthan could be. Last stated 3 months ago 21 Jul 2026 RT Ruxandra Teslo — holds since 2026-07-21 — tap for who they are Same subject: A celebrated popular science book can consistently misrepresent the literature it summarises and contradict its own sources. — tap to centre the map on it A celebrated popular science bookcan consistently misrepresent theliterature it summarises andcontradict its own sources. Last stated 7 years ago 15 Nov 2019 AG Alexey Guzey — holds since 2019-11-15 — tap for who they are Same subject: A conclusion being biologically reasonable is not the same as its having been proven. — tap to centre the map on it A conclusion being biologicallyreasonable is not the same as itshaving been proven. Last stated 3 months ago 11 Jul 2026 PA Peter Attia — holds since 2026-07-11 — tap for who they are Same subject: A drop in heart rate variability values typically precedes the onset of noticeable sickness symptoms by about a day. — tap to centre the map on it A drop in heart rate variabilityvalues typically precedes the onsetof noticeable sickness symptoms byabout a day. Last stated a month ago 18 Sept 2026 RM Ray Maker — holds since 2026-09-18 — tap for who they are Same subject: EFT tapping improves brain connectivity, heart rate variability, vagal tone, and reduces inflammation. — tap to centre the map on it EFT tapping improves brainconnectivity, heart ratevariability, vagal tone, and reducesinflammation. Last stated 2 years ago 21 Aug 2024 AS Arielle Schwartz — holds since 2024-08-21 — tap for who they are Same subject: Polyvagal theory survives the 2026 "untenable" critique: what the critics contested was mechanism and evolutionary framing, not the clinical proposition. — tap to centre the map on it Polyvagal theory survives the 2026"untenable" critique: what thecritics contested was mechanism andevolutionary framing, not theclinical proposition. Last stated 8 months ago 2 Mar 2026 AS Arielle Schwartz — holds since 2026-03-02 — tap for who they are Same subject: Regulation must precede reflection: cognitive insight fails while a nervous system is in defensive dominance. — tap to centre the map on it Regulation must precede reflection:cognitive insight fails while anervous system is in defensivedominance. Last stated 8 months ago 2 Mar 2026 AS Arielle Schwartz — holds since 2026-03-02 — tap for who they are Same subject: Keeping a social network, staying curious and having a sense of purpose protect against dementia about as much as blood pressure and exercise do. — tap to centre the map on it Keeping a social network, stayingcurious and having a sense ofpurpose protect against dementiaabout as much as blood pressure andexercise do. Last stated 2 months ago 24 Aug 2026 MH Masud Husain — holds since 2026-08-24 — tap for who they are Same subject: The dementia risk from short sleep starts below six hours a night, not below eight. — tap to centre the map on it The dementia risk from short sleepstarts below six hours a night, notbelow eight. Last stated 3 months ago 20 Jul 2026 TW Tommy Wood — holds since 2026-07-20 — tap for who they are Same subject: About half of all dementia is preventable, and most of that preventable half is Alzheimer's disease and vascular dementia. — tap to centre the map on it About half of all dementia ispreventable, and most of thatpreventable half is Alzheimer'sdisease and vascular dementia. Last stated 3 months ago 20 Jul 2026 TW Tommy Wood — holds since 2026-07-20 — tap for who they are
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At the centre Raising HDL cholesterol is not a treatment target, because every drug that raised it failed to reduce cardiovascular events. Last stated 27 Jun 2026 · 4 months ago Holds Peter Attia Read this korrent →