Raising HDL cholesterol is not a treatment target, because every drug that raised it failed to reduce cardiovascular events.

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• The phrase "good cholesterol" should be retired: a high HDL-C number is not a free pass on cardiovascular risk. PAPeter Attia27 Jun 2026
• The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. ATAlex Telford23 Dec 2023
• Non-risk-adjusted mortality data cannot support patient choice and only signal that a fuller review is required. DSDavid Spiegelhalter19 Aug 2004
• We have neither the data nor the insight to use machine learning to pick drug targets that succeed in the clinic more often. DLDerek Lowe25 May 2023
• Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. RTRuxandra Teslo21 Jul 2026

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