The patent system rewards novel chemical matter and not novel biology, so nobody is paid for validating a new drug target.

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• The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. ATAlex Telford23 Dec 2023
• Drug companies pile onto the same few already-validated targets, so far less of biology gets explored than could be. RTRuxandra Teslo21 Jul 2026
• Every new drug has to beat the cheap generics that came before it, and that competition with our own back catalogue is why drug discovery gets harder over time. DLDerek Lowe8 Mar 2012
• How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. ATAlex Telford23 Dec 2023
• Marketing returns are fat-tailed, so paying for marketing by the hour misprices work whose value comes from a small fraction of it. RSRory Sutherland9 Dec 2025

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