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← The bureaucracy around clinical trials is Chesterton's Fence: it was…
17 connected korrents · 17 moments from 19 Mar 2011 to 4 Oct 2026.
Everything filed under design
design
Everything filed under simplicity
simplicity
Everything filed under taste
taste
Everything filed under EMDR
EMDR
Everything filed under Psychotherapy
Psychotherapy
Everything filed under infrastructure
infrastructure
Everything filed under documentation
documentation
Everything filed under government
government In tension Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up. The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up. Last stated 6 years ago
1 May 2020
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
In tension: Environmental permitting now causes more environmental harm than it prevents, because what it delays is the clean thing replacing the dirty one. — tap to centre the map on it Environmental permitting now causes more environmental harm than it prevents, because what it delays is the clean thing replacing the dirty one. Last stated 3 years ago
10 Nov 2023
CH
Casey Handmer — holds since 2023-11-10 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. Last stated 8 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work. — tap to centre the map on it A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work. Last stated 2 years ago
11 Sept 2024
SM
Scott D. Miller — holds since 2024-09-11 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 3 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. — tap to centre the map on it Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. Last stated 6 years ago
1 May 2020
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
Same subject: When pharmaceutical companies act as top-down gatekeepers for which therapeutic ideas get pursued, promising innovations from startups can be overlooked. — tap to centre the map on it When pharmaceutical companies act as top-down gatekeepers for which therapeutic ideas get pursued, promising innovations from startups can be overlooked. Last stated 6 months ago
12 Apr 2026
EH
Elliot Hershberg — holds since 2026-04-12 — tap for who they are
Same subject: Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour. — tap to centre the map on it Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: When institutions can only offer compromised care they end up calling it best practice, and the patients who do not get better conclude that they themselves are beyond help. — tap to centre the map on it When institutions can only offer compromised care they end up calling it best practice, and the patients who do not get better conclude that they themselves are beyond help. Last stated 3 months ago
27 Jul 2026
JS
Jonathan Shedler — holds since 2026-07-27 — tap for who they are
Same subject: Large numbers of people are employed to care more about following approved procedure than about the quality of the outcome. — tap to centre the map on it Large numbers of people are employed to care more about following approved procedure than about the quality of the outcome. Last stated 10 months ago
9 Dec 2025
RS
Rory Sutherland — holds since 2025-12-09 — tap for who they are
Same subject: A business is more likely to fail from taking on too much complexity than from lacking resources. — tap to centre the map on it A business is more likely to fail from taking on too much complexity than from lacking resources. Last stated 8 years ago
29 Sept 2018
TG
Tren Griffin — holds since 2018-09-29 — tap for who they are
Same subject: A business succeeds through a small number of highly effective distribution channels, not many mediocre ones. — tap to centre the map on it A business succeeds through a small number of highly effective distribution channels, not many mediocre ones. Last stated 3 years ago
17 Feb 2024
AW
Adam Wiggins — holds since 2024-02-17 — tap for who they are
Same subject: A candidate negotiating an offer should make every ask fit one line of logic. — tap to centre the map on it A candidate negotiating an offer should make every ask fit one line of logic. Last stated 2 months ago
9 Aug 2026
AW
Adam Ward — holds since 2026-08-09 — tap for who they are
Same subject: A big part of taste is delivering high levels of craft in an accessible way so that as many people as possible can experience it. — tap to centre the map on it A big part of taste is delivering high levels of craft in an accessible way so that as many people as possible can experience it. Last stated 6 months ago
21 Apr 2026
BJ
Brandon Jacoby — holds since 2026-04-21 — tap for who they are
Same subject: A company name can have different appeal to corporate buyers versus their customers. — tap to centre the map on it A company name can have different appeal to corporate buyers versus their customers. Last stated 3 weeks ago
4 Oct 2026
PG
Paul Graham — holds since 2026-10-04 — tap for who they are
Same subject: A first draft should not be graded good or bad; it is only the material that taste then gets to act on. — tap to centre the map on it A first draft should not be graded good or bad; it is only the material that taste then gets to act on. Last stated 3 months ago
6 Aug 2026
GS
George Saunders — holds since 2026-08-06 — tap for who they are
Same subject: EMDR is an eight-phase treatment that starts with history-taking to find the memories and current situations that need addressing. — tap to centre the map on it EMDR is an eight-phase treatment that starts with history-taking to find the memories and current situations that need addressing. Last stated 16 years ago
19 Mar 2011
FS
Francine Shapiro — holds since 2011-03-19 — tap for who they are
Same subject: EMDR targets specific memories well but is not built for identity work or building a life narrative. — tap to centre the map on it EMDR targets specific memories well but is not built for identity work or building a life narrative. Last stated 7 months ago
7 Apr 2026
AW
Annie Wright — holds since 2026-04-07 — tap for who they are