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← The bureaucracy around clinical trials is Chesterton's Fence: it was…
16 connected korrents · 15 moments on record from 11 Jun 2006 to 27 Jul 2026.
Everything filed under Psychotherapy
Psychotherapy
Everything filed under simplicity
simplicity
Everything filed under design
design
Everything filed under infrastructure
infrastructure
Everything filed under documentation
documentation
Everything filed under CBT
CBT
Everything filed under EMDR
EMDR In tension Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up. The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up. Last stated 6 years ago
1 May 2020
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
In tension: Environmental permitting now causes more environmental harm than it prevents, because what it delays is the clean thing replacing the dirty one. — tap to centre the map on it Environmental permitting now causes more environmental harm than it prevents, because what it delays is the clean thing replacing the dirty one. Last stated 3 years ago
10 Nov 2023
CH
Casey Handmer — holds since 2023-11-10 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. Last stated 6 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work. — tap to centre the map on it A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work. Last stated 2 years ago
11 Sept 2024
SM
Scott D. Miller — holds since 2024-09-11 — tap for who they are
Same subject: The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. — tap to centre the map on it The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule. Last stated 2 months ago
21 Jul 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-07-21 — tap for who they are
Same subject: Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. — tap to centre the map on it Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer. Last stated 6 years ago
1 May 2020
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
Same subject: Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour. — tap to centre the map on it Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: When institutions can only offer compromised care they end up calling it best practice, and the patients who do not get better conclude that they themselves are beyond help. — tap to centre the map on it When institutions can only offer compromised care they end up calling it best practice, and the patients who do not get better conclude that they themselves are beyond help. Last stated a month ago
27 Jul 2026
JS
Jonathan Shedler — holds since 2026-07-27 — tap for who they are
Same subject: AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. — tap to centre the map on it AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much. Last stated a month ago
26 Jul 2026
DH
David Heinemeier Hansson — holds since 2026-07-26 — tap for who they are
Same subject: Convergence and simplicity make for poor goals in technology; aim for clarity instead. — tap to centre the map on it Convergence and simplicity make for poor goals in technology; aim for clarity instead. Last stated 12 years ago
18 Feb 2015
FC
Frank Chimero — holds since 2015-02-18 — tap for who they are
Same subject: Savings in time feel like simplicity: when forced to wait, life seems unnecessarily complex. — tap to centre the map on it Savings in time feel like simplicity: when forced to wait, life seems unnecessarily complex. Last stated 20 years ago
11 Jun 2006
JM
John Maeda — holds since 2006-06-11 — tap for who they are
Same subject: Action comes before motivation: you do first and feel afterwards, not the other way round. — tap to centre the map on it Action comes before motivation: you do first and feel afterwards, not the other way round. Last stated 11 months ago
30 Sept 2025
LF
Lex Fridman — holds since 2025-09-30 — tap for who they are
Same subject: "Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic". — tap to centre the map on it "Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic". Last stated 13 years ago
2 Oct 2013
JS
Jonathan Shedler — holds since 2013-10-02 — tap for who they are
Same subject: No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often. — tap to centre the map on it No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often. Last stated 13 years ago
2 Oct 2013
JS
Jonathan Shedler — holds since 2013-10-02 — tap for who they are
Same subject: Eye movement reprocessing went from alternative to establishment, and moving your eyes while talking about a trauma does seem to help you process it. — tap to centre the map on it Eye movement reprocessing went from alternative to establishment, and moving your eyes while talking about a trauma does seem to help you process it. Last stated 7 years ago
12 Nov 2019
SA
Scott Alexander — holds since 2019-11-12 — tap for who they are
Same subject: If negative emotion comes from underweighting sensory evidence, that explains EMDR: it forces high-precision attention onto something the mind usually represses. — tap to centre the map on it If negative emotion comes from underweighting sensory evidence, that explains EMDR: it forces high-precision attention onto something the mind usually represses. Last stated 6 years ago
13 Feb 2021
SA
Scott Alexander — holds since 2021-02-13 — tap for who they are
Same subject: Somebody with trauma should try a trauma-focused therapy such as EMDR before treating their nightmares directly. — tap to centre the map on it Somebody with trauma should try a trauma-focused therapy such as EMDR before treating their nightmares directly. Last stated 4 years ago
16 Jun 2022
SA
Scott Alexander — holds since 2022-06-16 — tap for who they are
At the centre
The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up.
Holds DL Derek LoweRead this korrent →
Environmental permitting now causes more environmental harm than it prevents, because what it delays is the clean thing replacing the dirty one.
Holds CH Casey Handmer
Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.
Holds RT Ruxandra Teslo
A therapy is only shown to be more effective if it is compared against another treatment intended to help, not against a control nobody expected to work.
Holds SM Scott D. Miller
The hard part of drug discovery is knowing what to make - which target is worth drugging - not designing the molecule.
Holds AT Alex TelfordRT Ruxandra Teslo
Standardised manufacturing and documentation cannot be skipped when a drug is given to human beings, because the noise they remove is the noise that would otherwise swallow the answer.
Holds DL Derek Lowe
Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour.
Holds AT Alex Telford
When institutions can only offer compromised care they end up calling it best practice, and the patients who do not get better conclude that they themselves are beyond help.
Holds JS Jonathan Shedler
AI acceleration threatens 'less software': without the constraint of scarce hours, even 37signals will likely build too much.
Holds
Convergence and simplicity make for poor goals in technology; aim for clarity instead.
Holds FC Frank Chimero
Savings in time feel like simplicity: when forced to wait, life seems unnecessarily complex.
Holds JM John Maeda
Action comes before motivation: you do first and feel afterwards, not the other way round.
Holds LF Lex Fridman
"Evidence-based therapy" is a branding term rather than a scientific one, and in practice it is a code word for "not psychodynamic".
Holds JS Jonathan Shedler
No research ever showed manualized CBT to be more effective than psychodynamic therapy; it was only studied more often.
Holds JS Jonathan Shedler
Eye movement reprocessing went from alternative to establishment, and moving your eyes while talking about a trauma does seem to help you process it.
Holds SA Scott Alexander
If negative emotion comes from underweighting sensory evidence, that explains EMDR: it forces high-precision attention onto something the mind usually represses.
Holds SA Scott Alexander
Somebody with trauma should try a trauma-focused therapy such as EMDR before treating their nightmares directly.
Holds SA Scott Alexander