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← Sex is not an option but a requirement: a large genome cannot be…
13 connected korrents · 10 moments from 15 Jul 2021 to 30 Jul 2026.
Everything filed under AI and science
AI and science
Everything filed under evolutionary biology
evolutionary biology
Everything filed under design
design Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Sex is not an option but a requirement: a large genome cannot be maintained by picking up loose DNA, so eukaryotes were forced into it. Sex is not an option but a requirement: a large genome cannot be maintained by picking up loose DNA, so eukaryotes were forced into it. Last stated 4 years ago
7 Sept 2022
NL
Nick Lane — holds since 2022-09-07 — tap for who they are
Same subject: Natural selection in humans has not been quiescent: it is tugging almost every position in the genome in one direction or another, everywhere. — tap to centre the map on it Natural selection in humans has not been quiescent: it is tugging almost every position in the genome in one direction or another, everywhere. Last stated 6 months ago
8 May 2026
DR
David Reich — holds since 2026-05-08 — tap for who they are
Same subject: Ancient DNA has been a triumph about migration and a failure about biology, and the reason is simply that the samples were too small. — tap to centre the map on it Ancient DNA has been a triumph about migration and a failure about biology, and the reason is simply that the samples were too small. Last stated 6 months ago
8 May 2026
DR
David Reich — holds since 2026-05-08 — tap for who they are
Same subject: Bacteria never became complex because the barrier is structure, not information — they explored genetic space far more thoroughly than eukaryotes and still got stuck. — tap to centre the map on it Bacteria never became complex because the barrier is structure, not information — they explored genetic space far more thoroughly than eukaryotes and still got stuck. Last stated 4 years ago
7 Sept 2022
NL
Nick Lane — holds since 2022-09-07 — tap for who they are
Same subject: Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli. — tap to centre the map on it Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli. Last stated a year ago
29 Jun 2025
EH
Elliot Hershberg — holds since 2025-06-29 — tap for who they are
Same subject: A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. — tap to centre the map on it A compound's AI origin story is not by itself a reason to expect it to do better in the clinic. Last stated 2 years ago
13 May 2024
DL
Derek Lowe — holds since 2024-05-13 — tap for who they are
Same subject: A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck. — tap to centre the map on it A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck. Last stated 2 years ago
17 Sept 2024
AT
Alex Telford — holds since 2024-09-17 — tap for who they are
Same subject: A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. — tap to centre the map on it A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: A language model's apparent mind is mostly our own bias: it predicts text, and leverages our evolved habit of attributing intentionality to anything that acts human. — tap to centre the map on it A language model's apparent mind is mostly our own bias: it predicts text, and leverages our evolved habit of attributing intentionality to anything that acts human. Last stated 3 years ago
22 Apr 2024
SC
Sean Carroll — holds since 2024-04-22 — tap for who they are
Same subject: A selection signal can be validated without a significance threshold, by measuring how far it is enriched for mutations an entirely independent study says affect a trait. — tap to centre the map on it A selection signal can be validated without a significance threshold, by measuring how far it is enriched for mutations an entirely independent study says affect a trait. Last stated 6 months ago
8 May 2026
DR
David Reich — holds since 2026-05-08 — tap for who they are
Same subject: Adaptive evolution tends to achieve even a simple, fixed objective through complicated behavior. — tap to centre the map on it Adaptive evolution tends to achieve even a simple, fixed objective through complicated behavior. Last stated 5 months ago
4 Jun 2026
SW
Stephen Wolfram — holds since 2026-06-04 — tap for who they are
Same subject: A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. — tap to centre the map on it A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. Last stated 3 months ago
30 Jul 2026
JD
Jeff Dean — holds since 2026-07-30 — tap for who they are
Same subject: Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. — tap to centre the map on it Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics. Last stated 5 years ago
15 Jul 2021
DH
Demis Hassabis — holds since 2021-07-15 — tap for who they are
Same subject: AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points. — tap to centre the map on it AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points. Last stated 11 months ago
23 Nov 2025
EH
Elliot Hershberg — holds since 2025-11-23 — tap for who they are
At the centre
Sex is not an option but a requirement: a large genome cannot be maintained by picking up loose DNA, so eukaryotes were forced into it.
Holds Read this korrent →
Natural selection in humans has not been quiescent: it is tugging almost every position in the genome in one direction or another, everywhere.
Holds
Ancient DNA has been a triumph about migration and a failure about biology, and the reason is simply that the samples were too small.
Holds
Bacteria never became complex because the barrier is structure, not information — they explored genetic space far more thoroughly than eukaryotes and still got stuck.
Holds
Building a mechanistic whole-cell model of a human cell is far more uncertain in timeline than doing so for simpler organisms like E. coli.
Holds
A compound's AI origin story is not by itself a reason to expect it to do better in the clinic.
Holds
A computational discovery platform does not make a biotech fast, because the thousand other steps of drug development are still the bottleneck.
Holds
A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known.
Holds
A language model's apparent mind is mostly our own bias: it predicts text, and leverages our evolved habit of attributing intentionality to anything that acts human.
Holds
A selection signal can be validated without a significance threshold, by measuring how far it is enriched for mutations an entirely independent study says affect a trait.
Holds
Adaptive evolution tends to achieve even a simple, fixed objective through complicated behavior.
Holds
A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next.
Holds
Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics.
Holds
AI models can be more accurate than physical experiments by averaging out noise, incorporating priors from large datasets, and interpolating between data points.
Holds