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← Clinical trials cost what they do because they are complex,…
15 connected korrents · 15 moments from 30 Aug 2005 to 24 Sept 2026.
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LLMs Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Same subject Read this korrent: Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour. Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour. Last stated 3 years ago
23 Dec 2023
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
Same subject: Demanding that research be done cheaply tends to make it the most expensive kind of research. — tap to centre the map on it Demanding that research be done cheaply tends to make it the most expensive kind of research. Last stated 5 years ago
3 Jun 2021
GW
Gwern — holds since 2021-06-03 — tap for who they are
Same subject: Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. — tap to centre the map on it Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is. Last stated 8 months ago
28 Feb 2026
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: When experiments are cheap, approval chains are the expensive part. — tap to centre the map on it When experiments are cheap, approval chains are the expensive part. Last stated a month ago
10 Sept 2026
EV
Elena Verna — holds since 2026-09-10 — tap for who they are
Same subject: The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up. — tap to centre the map on it The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up. Last stated 6 years ago
1 May 2020
DL
Derek Lowe — holds since 2020-05-01 — tap for who they are
Same subject: How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. — tap to centre the map on it How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly. Last stated 8 months ago
28 Feb 2026
AT
Alex Telford — holds since 2023-12-23 — tap for who they are
RT
Ruxandra Teslo — holds since 2026-02-28 — tap for who they are
Same subject: An AI as good as a top researcher will not be priced like one, because it competes against the other labs rather than against humans. — tap to centre the map on it An AI as good as a top researcher will not be priced like one, because it competes against the other labs rather than against humans. Last stated a year ago
15 Aug 2025
CH
Casey Handmer — holds since 2025-08-15 — tap for who they are
Same subject: A $1,299, 100-gram pair of slip-on glasses seems far more enticing than a $3,699, 700-gram headset strapped to the face. — tap to centre the map on it A $1,299, 100-gram pair of slip-on glasses seems far more enticing than a $3,699, 700-gram headset strapped to the face. Last stated 4 weeks ago
24 Sept 2026
MS
M.G. Siegler — holds since 2026-09-24 — tap for who they are
Same subject: A baby-step version of eval-driven design is to sketch out 10 to 20 hero flows and run the feature or interaction through them to see where it falls apart. — tap to centre the map on it A baby-step version of eval-driven design is to sketch out 10 to 20 hero flows and run the feature or interaction through them to see where it falls apart. Last stated a month ago
9 Sept 2026
EB
Ed Bayes — holds since 2026-09-09 — tap for who they are
Same subject: A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. — tap to centre the map on it A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do. Last stated a year ago
12 May 2025
JZ
Julie Zhuo — holds since 2025-05-12 — tap for who they are
Same subject: “Trust science” is a confused instruction: what deserves trust is the process, not any particular thing it has concluded so far. — tap to centre the map on it “Trust science” is a confused instruction: what deserves trust is the process, not any particular thing it has concluded so far. Last stated 3 years ago
16 Aug 2023
JC
Jason Crawford — holds since 2023-08-16 — tap for who they are
Same subject: A hotter field with more teams racing on the same question produces less reliable findings, not more. — tap to centre the map on it A hotter field with more teams racing on the same question produces less reliable findings, not more. Last stated 21 years ago
30 Aug 2005
JI
John Ioannidis — holds since 2005-08-30 — tap for who they are
Same subject: A hyped effect shrinking to a small but real one as the studies improve is a sign that a field is working, not failing. — tap to centre the map on it A hyped effect shrinking to a small but real one as the studies improve is a sign that a field is working, not failing. Last stated 4 years ago
11 Oct 2022
SR
Stuart Ritchie — holds since 2022-10-11 — tap for who they are
Same subject: A browser works better as a single window than as multiple separate windows. — tap to centre the map on it A browser works better as a single window than as multiple separate windows. Last stated a month ago
15 Sept 2026
CC
Chris Coyier — holds since 2026-09-15 — tap for who they are
Same subject: A business is more likely to fail from taking on too much complexity than from lacking resources. — tap to centre the map on it A business is more likely to fail from taking on too much complexity than from lacking resources. Last stated 8 years ago
29 Sept 2018
TG
Tren Griffin — holds since 2018-09-29 — tap for who they are
Same subject: A business succeeds through a small number of highly effective distribution channels, not many mediocre ones. — tap to centre the map on it A business succeeds through a small number of highly effective distribution channels, not many mediocre ones. Last stated 3 years ago
17 Feb 2024
AW
Adam Wiggins — holds since 2024-02-17 — tap for who they are
At the centre
Clinical trials cost what they do because they are complex, bureaucratic and reliant on highly skilled labour.
Holds Read this korrent →
Demanding that research be done cheaply tends to make it the most expensive kind of research.
Holds
Better drug candidates do not shorten clinical trials, because a trial's duration is set by operational and regulatory friction rather than by how good the drug is.
Holds
When experiments are cheap, approval chains are the expensive part.
Holds
The bureaucracy around clinical trials is Chesterton's Fence: it was built on the harm done by sloppier trials and should not be pulled down without knowing why it went up.
Holds
How long a trial takes decides which diseases get drugs at all, because capital flows to the indications whose endpoints can be measured quickly.
Holds
An AI as good as a top researcher will not be priced like one, because it competes against the other labs rather than against humans.
Holds
A $1,299, 100-gram pair of slip-on glasses seems far more enticing than a $3,699, 700-gram headset strapped to the face.
Holds
A baby-step version of eval-driven design is to sketch out 10 to 20 hero flows and run the feature or interaction through them to see where it falls apart.
Holds
A blank chat box is lazy: it violates the first rule of a good user experience, that it is obvious what you can do.
Holds
“Trust science” is a confused instruction: what deserves trust is the process, not any particular thing it has concluded so far.
Holds
A hotter field with more teams racing on the same question produces less reliable findings, not more.
Holds
A hyped effect shrinking to a small but real one as the studies improve is a sign that a field is working, not failing.
Holds
A browser works better as a single window than as multiple separate windows.
Holds
A business is more likely to fail from taking on too much complexity than from lacking resources.
Holds
A business succeeds through a small number of highly effective distribution channels, not many mediocre ones.
Holds