The Biochemical Beauty of Retatrutide: How GLP-1s Actually Work

Elizabeth Van Nostrand · 13 Oct 2025

Elizabeth Van Nostrand did not write this page.

Every claim below was made in this piece, quoted word for word and numbered in the order the piece makes them, so you can read it there rather than take our word for it. The sentence above each quote is our reading of the claim, not their wording. Each quote was checked against a stored copy of the page at build time; where the two differ, the quote is the fact.

Our reading
The body prefers to use glycogen over fat for energy because converting glycogen wastes far less energy than converting fat.

Their wordsIn general your body would rather use glycogen than fat, because glycogen loses almost no energy in the conversion from and to sugar and fat loses a lot.
Our reading
Cortisol promotes fat storage and muscle breakdown and increases insulin resistance.

Their wordsempirically cortisol promotes fat storage and muscle breakdown, and increases insulin resistance.
Our reading
Semaglutide and tirzepatide increase the rate of thyroid tumors in rodent studies.

Their wordsIn rodent studies, semaglutide and tirzepatide were both found to increase the rate of thyroid tumors.

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