Trials of omega-3s and of B vitamins keep coming back null because the two depend on one another, and supplementing either while the other is low does nothing.

But there are now at least three randomized control trials that have shown that omega-3 status and B vitamin status interact and they're dependent on one another. So, if you give uh B vitamins to somebody who has elevated homocyine, you bring down their homocyine, but they have poor omega-3 levels, you don't see any benefit.