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Kevin Esvelt

@kevin-esvelt · 6 positions · 0 changes of mind

Evolutionary and ecological engineer, professor at the MIT Media Lab, where he leads the Sculpting Evolution group. He first described CRISPR-based gene drives and then argued publicly for constraining them; he now works mainly on biosecurity - DNA synthesis screening, pathogen-agnostic early detection, and keeping pandemic-capable sequences out of circulation.

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  1. It should be hard — exceedingly hard — to obtain the synthetic DNA needed to recreate the virus that caused the deadly 1918 influenza pandemic without authorization. But my lab found that it’s surprisingly easy, even when ordering gene fragments from companies that check customers’ orders to detect hazardous sequences.

    It shouldn't be easy to buy synthetic DNA fragments to recreate the 1918 flu virusmedia.mit.edu 1st of 4 in this piece

  2. Our experiment demonstrates that the immense potential benefits of biotechnology are profoundly vulnerable to misuse.

    It shouldn't be easy to buy synthetic DNA fragments to recreate the 1918 flu virusmedia.mit.edu 2nd of 4 in this piece

  3. Both the genome sequences of pandemic viruses and step-by-step protocols to make infectious samples from synthetic DNA are now freely available online.

    It shouldn't be easy to buy synthetic DNA fragments to recreate the 1918 flu virusmedia.mit.edu 3rd of 4 in this piece

  4. That makes it essential to ensure that all synthetic DNA orders are screened to determine whether they contain hazardous sequences, which should be shipped only to legitimate researchers whose work has been approved by a biosafety authority.

    It shouldn't be easy to buy synthetic DNA fragments to recreate the 1918 flu virusmedia.mit.edu 4th of 4 in this piece

  5. 3 years earlier
  6. But perhaps the biggest question of all isn’t being asked insistently enough: Why is anyone trying to teach the world how to make viruses that could kill millions of people?

    Opinion: Manipulating viruses and risking pandemics is too dangerous. It's time to stop.media.mit.edu 1st of 2 in this piece

  7. Like nuclear physics, with its potential for global catastrophe when put to destructive ends, the proliferation of pandemic biology ought to be considered a matter of international security.

    Opinion: Manipulating viruses and risking pandemics is too dangerous. It's time to stop.media.mit.edu 2nd of 2 in this piece

    physics