What John Mandrola thinks about design
Cardiac electrophysiologist in Louisville, Kentucky. Co-writes the Sensible Medicine newsletter, where he reviews cardiology and other clinical trials, and blogs at drjohnm.org.
John Mandrola did not write this page.
We collected these quotes from things they published elsewhere, and every quote links to where it was said. They have no account here and have not endorsed this site. Quotes are word for word; the short line under each one is our own restatement, not their wording. Their own site. Is this you? Claim it or ask us to remove it. Or tell us what is wrong here.
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1 dated position, 2026, in their own words. Our reading of what John Mandrola has said — not written or endorsed by them.
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Their wordsThe endpoint that drove the results were open to bias in this open label trial. In the win ratio, the HF hospitalization endpoint did the work: 9,280 vs 2,871 wins. Death rates were close (4,366 vs 3,166), and 74% of pairs were tied on death. Hospitalization, of course, is a clinician decision. Since everyone knows the treatment assignment, it's easy to give an increase in oral diuretics to a patient with a device while admitting a patient without one.