Read the piece on vajenda.substack.com ↗
Every claim below was made in this piece, quoted word for word and numbered in the order the piece makes them, so you can read it there rather than take our word for it. The sentence above each quote is our reading of the claim, not their wording. Each quote was checked against a stored copy of the page at build time; where the two differ, the quote is the fact.
Their wordsWhile guidelines don't compel anyone, they can influence insurers, pharmacy benefit managers, or governments to cover therapies and may also affect the price.
Our reading
The ACP guideline's exclusion of tibolone lacks sufficient evidence to justify safety concerns.
Their wordsThe guideline excluded tibolone for what the authors write are "safety reasons," but they provide no analysis showing why its safety profile would preclude its use for hot flashes and night sweats.
Their wordsDemoting a drug to a third tier based on cost becomes a self-fulfilling prophecy, as many insurers and pharmacy benefit managers look at these tiers to design coverage or as excuses to exclude the more expensive drugs.
Keep reading