Biology has already handed us an alien library: hundreds of millions of protein machines we do not understand and can only study one at a time.

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• Biology keeps turning up whole classes of things nobody knew existed, and that is what defeats attempts to model it. DLDerek Lowe19 Sept 2024similar wording
• Most proteins have no known function, so there is no pile of solid data for a model to learn most of cell biology from. DLDerek Lowe19 Sept 2024similar wording
• AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. DLDerek Lowe19 Sept 2024similar wording
• A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. JDJeff Dean30 Jul 2026similar wording
• No single person can understand a result like the Higgs boson in depth, and that is what a paper with a thousand authors actually means. MNMichael Nielsen7 Apr 2026similar wording

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