Accurate computational approaches are needed to close the protein structural coverage gap and enable large-scale structural bioinformatics.

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• Existing protein structure prediction methods fall far short of atomic accuracy when no homologous structure is available. DHDemis Hassabis15 Jul 2021similar wording
• A computational method can regularly predict protein structures with atomic accuracy even when no similar structure is known. DHDemis Hassabis15 Jul 2021similar wording
• A narrow, highly accurate model can beat a general one inside its own domain, as AlphaFold did, and materials science and chip design are next. JDJeff Dean30 Jul 2026similar wording
• Contemporary physical and evolutionary structure-prediction approaches fall far short of experimental accuracy without a close experimental homologue, limiting biological utility. DHDemis Hassabis15 Jul 2021similar wording
• AI will not produce a big breakthrough in biological understanding any time soon, because biology has nothing like the clean, complete, high-quality data that made protein-structure prediction work. DLDerek Lowe19 Sept 2024similar wording

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