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Sensible Medicine

John Mandrola · 6 Jul 2026

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  1. Enter the polypill: what if you could take one tablet that had multiple drugs in it? This reduces the work of being a patient and it may even increase adherence to beneficial drugs.
  2. This, I think, is one of the major limitations of polypill data: namely, that you have to be highly selected to be eligible for a polypill.
  3. What's more. the difference in EF in this trial was only 3%-a number that reached statistical significance, but it's not clinically significant.

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